Preclinical and clinical applications of specific molecular imaging for HER2-positive breast cancer.
Preclinical and clinical applications of specific molecular imaging for HER2-positive breast cancer.
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特异性分子成像在HER2阳性乳腺癌中的临床前和临床应用。
DOI：
10.20892/j.issn.2095-3941.2017.0044
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发表时间：
2017-08
影响因子：
5.5
通讯作者：
Wang P
中科院分区：
文献类型：
--
作者：
Chen W;Li X;Zhu L;Liu J;Xu W;Wang P
精准医疗和个性化治疗正受到越来越多的关注，分子亚型分类已成为乳腺癌患者临床实践中规划治疗方案的关键。人表皮生长因子受体2（HER2）与高级别乳腺肿瘤、高淋巴结受累率、高复发风险和对一般化疗的高耐药性相关。HER2表达分析对于医生识别可以从曲妥珠单抗治疗中获益的患者并监测治疗的反应和疗效非常重要。近年来，人们一直致力于实现特异性和非侵入性的HER2阳性乳腺癌体内成像。本文回顾了近十年来国内外有关HER2显像的文献，并从显像方式、HER2特异性探针等不同角度对研究进行了总结。我们的目的是提高对HER2乳腺癌分子成像中的翻译过程的理解。
Precision medicine and personalized therapy are receiving increased attention, and molecular-subtype classification has become crucial in planning therapeutic schedules in clinical practice for patients with breast cancer. Human epidermal growth factor receptor 2 (HER2) is associated with high-grade breast tumors, high rates of lymph-node involvement, high risk of recurrence, and high resistance to general chemotherapy. Analysis of HER2 expression is highly important for doctors to identify patients who can benefit from trastuzumab therapy and monitor the response and efficacy of treatment. In recent years, significant efforts have been devoted to achieving specific and noninvasive HER2-positive breast cancer imaging in vivo. In this work, we reviewed existing literature on HER2 imaging in the past decade and summarized the studies from different points of view, such as imaging modalities and HER2-specific probes. We aimed to improve the understanding on the translational process in molecular imaging for HER2 breast cancer.
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