f = m*a: A Framework for Investigating the Regulation of Replication Timing.
f = m*a: A Framework for Investigating the Regulation of Replication Timing.
复制标题
DOI：
10.3390/genes13020249
复制
发表时间：
2022-01-28
期刊：
影响因子：
3.5
通讯作者：
Rhind N
中科院分区：
文献类型：
--
作者：
Rhind N
复制定时的随机模型表明，原点发射定时由原点发射概率调节，早发射原点具有高的发射概率，晚发射原点具有较低的概率。然而，他们没有提供任何见解，为什么一个起源应该比另一个有更高的发射概率。在这里，一个简单的框架，建议如何处理的问题，注意到发射概率（f）必须是产品的化学计量的MCM复制解旋酶装载在原点（m）和MCM被激活的概率（a）。这个框架强调，复制时机的机械理解必须集中在MCM加载和激活，并可以简化为方程f = m*a。
Stochastic models of replication timing posit that origin firing timing is regulated by origin firing probability, with early-firing origins having a high probability of firing and late-firing origins having a lower probability. However, they offer no insight into why one origin should have a higher firing probability than another. Here, a simple framework is suggested for how to approach the question by noting that the firing probability (f) must be the product of the stoichiometry of the MCM replicative helicase loaded at the origin (m) and the probability with which that MCM is activated (a). This framework emphasizes that mechanistic understanding of replication timing must focus on MCM loading and activation and can be simplified to the equation f = m*a.
登录
查看更多内容
影响因子：
7.7
作者：
Gupta S;Friedman LJ;Gelles J;Bell SP
通讯作者：
Bell SP
影响因子：
7.5
作者：
Fu H;Baris A;Aladjem MI
通讯作者：
Aladjem MI
影响因子：
14.9
作者：
Labit, Helene;Perewoska, Irene;Marheineke, Kathrin
通讯作者：
Marheineke, Kathrin
影响因子：
10.5
作者：
Eaton, Matthew L.;Galani, Kyriaki;MacAlpine, David M.
通讯作者：
MacAlpine, David M.
影响因子：
64.5
作者：
Knott SR;Peace JM;Ostrow AZ;Gan Y;Rex AE;Viggiani CJ;Tavaré S;Aparicio OM
通讯作者：
Aparicio OM