Critical Role for AMPK in Metabolic Disease-Induced Chronic Kidney Disease.
Critical Role for AMPK in Metabolic Disease-Induced Chronic Kidney Disease.
复制标题
DOI：
10.3390/ijms21217994
复制
发表时间：
2020-10-27
影响因子：
5.6
通讯作者：
Declèves AE
中科院分区：
文献类型：
--
作者：
Juszczak F;Caron N;Mathew AV;Declèves AE
慢性肾脏疾病(CKD)在全球9.1%的人口中流行，是一个与发病率和死亡率增加相关的重大公共卫生问题。慢性肾脏病与高血压、肥胖、胰岛素抵抗、心血管疾病和衰老等常见的生理和代谢紊乱有关，也是慢性肾脏病发生和发展的危险因素。肾脏的足细胞和近端小管细胞强烈表达AMP激活的蛋白激酶(AMPK)。AMPK在糖脂代谢、细胞生存、生长和炎症中发挥重要作用。因此，代谢性疾病引起的肾脏疾病，如肥胖相关疾病和糖尿病慢性肾脏疾病，表现出肾脏AMPK调节失调。激活AMPK可改善这两种疾病的病理和表型特征。作为一种代谢感受器，AMPK调节活跃的肾小管运输，帮助肾细胞在低能量状态下存活。AMPK还在线粒体动态平衡中发挥关键作用，并被认为调节哺乳动物细胞的自噬。虽然AMPK的营养感知作用在决定肾脏细胞的命运中至关重要，但AMPK在代谢性疾病相关CKD的肾脏自噬和导致病理的线粒体质量控制中的作用还不是很清楚，需要进一步研究。这篇综述强调了AMPK在与代谢性疾病相关的肾细胞功能障碍中的关键作用，旨在通过了解CKD的分子和细胞过程来扩展治疗策略。
Chronic kidney disease (CKD) is prevalent in 9.1% of the global population and is a significant public health problem associated with increased morbidity and mortality. CKD is associated with highly prevalent physiological and metabolic disturbances such as hypertension, obesity, insulin resistance, cardiovascular disease, and aging, which are also risk factors for CKD pathogenesis and progression. Podocytes and proximal tubular cells of the kidney strongly express AMP-activated protein kinase (AMPK). AMPK plays essential roles in glucose and lipid metabolism, cell survival, growth, and inflammation. Thus, metabolic disease-induced renal diseases like obesity-related and diabetic chronic kidney disease demonstrate dysregulated AMPK in the kidney. Activating AMPK ameliorates the pathological and phenotypical features of both diseases. As a metabolic sensor, AMPK regulates active tubular transport and helps renal cells to survive low energy states. AMPK also exerts a key role in mitochondrial homeostasis and is known to regulate autophagy in mammalian cells. While the nutrient-sensing role of AMPK is critical in determining the fate of renal cells, the role of AMPK in kidney autophagy and mitochondrial quality control leading to pathology in metabolic disease-related CKD is not very clear and needs further investigation. This review highlights the crucial role of AMPK in renal cell dysfunction associated with metabolic diseases and aims to expand therapeutic strategies by understanding the molecular and cellular processes underlying CKD.
登录
查看更多内容
影响因子：
13.5
作者：
Dai H;Sinclair DA;Ellis JL;Steegborn C
通讯作者：
Steegborn C
DOI：
10.1007/978-3-319-43589-3_6
发表时间：
2016-01-01
期刊：
AMP-ACTIVATED PROTEIN KINASE
影响因子：
--
作者：
Bullon, Pedro;Marin-Aguilar, Fabiola;Roman-Malo, Lourdes
通讯作者：
Roman-Malo, Lourdes
影响因子：
4.8
作者：
Bhalla, Vivek;Oyster, Nicholas M.;Hallows, Kenneth R.
通讯作者：
Hallows, Kenneth R.
影响因子：
5.6
作者：
Castilla-Madrigal, Rosa;Barrenetxe, Jaione;Pilar Lostao, Maria
通讯作者：
Pilar Lostao, Maria
影响因子：
2.8
作者：
Dermaku-Sopjani, Miribane;Almilaji, Ahmad;Lang, Florian
通讯作者：
Lang, Florian