An examination of male and female odds ratios by BMI, cigarette smoking, and alcohol consumption for cancers of the oral cavity, pharynx, and larynx in pooled data from 15 case-control studies.
An examination of male and female odds ratios by BMI, cigarette smoking, and alcohol consumption for cancers of the oral cavity, pharynx, and larynx in pooled data from 15 case-control studies.
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DOI：
10.1007/s10552-011-9792-x
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发表时间：
2011-09
影响因子：
2.3
通讯作者：
Hashibe, Mia
中科院分区：
文献类型：
--
作者：
Lubin, Jay H.;Muscat, Joshua;Gaudet, Mia M.;Olshan, Andrew F.;Curado, Maria Paula;Dal Maso, Luigino;Wuensch-Filho, Victor;Sturgis, Erich M.;Szeszenia-Dabrowska, Neonilia;Castellsague, Xavier;Zhang, Zuo-Feng;Smith, Elaine;Fernandez, Leticia;Matos, Elena;Franceschi, Silvia;Fabianova, Eleonora;Rudnai, Peter;Purdue, Mark P.;Mates, Dana;Wei, Qingyi;Herrero, Rolando;Kelsey, Karl;Morgenstern, Hal;Shangina, Oxana;Koifman, Sergio;Lissowska, Jolanta;Levi, Fabio;Daudt, Alexander W.;Eluf Neto, Jose;Chen, Chu;Lazarus, Philip;Winn, Deborah M.;Schwartz, Stephen M.;Boffetta, Paolo;Brennan, Paul;Menezes, Ana;La Vecchia, Carlo;McClean, Michael;Talamini, Renato;Rajkumar, Thangarajan;Hayes, Richard B.;Hashibe, Mia
吸烟和饮酒增加以及身体质量指数（BMI）降低会增加口腔癌、口咽癌、下咽癌和喉癌的优势比（OR）；然而，没有针对这些因素的全面的性别特异性的ORs比较。我们分析了来自insance联盟15项头颈癌病例对照研究的2441例口腔（925例女性，1516例男性）、2297例口咽部（564例女性，1733例男性）、508例下咽（96例女性，412例男性）和1740例喉部（237例女性，1503例男性）病例。根据分析结果，控制对象从7604人到13829人不等。分析拟合的线性指数过剩ORs模型。相对于超重和肥胖类别（BMI≥25），体重不足（BMI <18.5）的or值在所有部位均增加，且性别均匀。女性吸烟和饮酒导致的ORs在口咽癌中显著高于男性（两种因素均p<0.01），提示下咽癌（p=0.05和p=0.06），但在口腔癌（p=0.56和p=0.64）和喉癌（p=0.18和p=0.72）中均相同。口咽癌和下咽癌的性别吸烟和饮酒的OR改变在多大程度上代表了真正的关联，或源于未测量的混杂因素或未观察到的性别相关疾病亚型（例如，人乳头瘤病毒阳性口咽癌），仍有待澄清。
Greater tobacco smoking and alcohol consumption and lower body mass index (BMI) increase odds ratios (OR) for oral cavity, oropharyngeal, hypopharyngeal and laryngeal cancers; however, there are no comprehensive sex-specific comparisons of ORs for these factors. We analyzed 2,441 oral cavity (925 females and 1,516 males), 2,297 oropharynx (564 females and 1,733 males), 508 hypopharynx (96 females and 412 males) and 1,740 larynx (237 females and 1,503 males) cases from the INHANCE consortium of 15 head and neck cancer case-control studies. Controls numbered from 7,604 to 13,829 subjects, depending on analysis. Analyses fitted linear-exponential excess ORs models. ORs were increased in underweight (<18.5 BMI) relative to overweight and obese categories (≥25 BMI) for all sites and were homogeneous by sex. ORs by smoking and drinking in females compared to males were significantly greater for oropharyngeal cancer (p<0.01 for both factors), suggestive for hypopharyngeal cancer (p=0.05 and p=0.06, respectively), but homogeneous for oral cavity (p=0.56 and p=0.64) and laryngeal (p=0.18 and p=0.72) cancers. The extent that OR modifications of smoking and drinking by sex for oropharyngeal and, possibly, hypopharyngeal cancers represent true associations, or derive from unmeasured confounders or unobserved sex-related disease subtypes (e.g., human papillomavirus positive oropharyngeal cancer) remains to be clarified.
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影响因子：
5
作者：
Freedman, Neal D.;Abnet, Christian C.;Schatzkin, Arthur
通讯作者：
Schatzkin, Arthur
影响因子：
2
作者：
DURRLEMAN, S;SIMON, R
通讯作者：
SIMON, R
影响因子：
2.3
作者：
Hayes, RB;Bravo-Otero, E;Winn, DM
通讯作者：
Winn, DM
影响因子：
7.7
作者：
Gaudet, Mia M.;Olshan, Andrew F.;Hashibe, Mia
通讯作者：
Hashibe, Mia
DOI：
10.1093/jnci/djk179
发表时间：
2007-05-16
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Hashibe, Mia;Brennan, Paul;Boffetta, Paolo
通讯作者：
Boffetta, Paolo