Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K.
Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K.
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DOI：
10.3389/fmed.2021.697605
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发表时间：
2021
影响因子：
3.9
通讯作者：
Mercado-Reyes M
中科院分区：
文献类型：
--
作者：
Laiton-Donato K;Usme-Ciro JA;Franco-Muñoz C;Álvarez-Díaz DA;Ruiz-Moreno HA;Reales-González J;Prada DA;Corchuelo S;Herrera-Sepúlveda MT;Naizaque J;Santamaría G;Wiesner M;Walteros DM;Ospina Martínez ML;Mercado-Reyes M
COVID-19 pandemics has led to genetic diversification of SARS-CoV-2 and the appearance of variants with potential impact in transmissibility and viral escape from acquired immunity. We report a new and highly divergent lineage containing 21 distinctive mutations (10 non-synonymous, eight synonymous, and three substitutions in non-coding regions). The amino acid changes L249S and E484K located at the CTD and RBD of the Spike protein could be of special interest due to their potential biological role in the virus-host relationship. Further studies are required for monitoring the epidemiologic impact of this new lineage.
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影响因子：
7.7
作者：
Weisblum Y;Schmidt F;Zhang F;DaSilva J;Poston D;Lorenzi JC;Muecksch F;Rutkowska M;Hoffmann HH;Michailidis E;Gaebler C;Agudelo M;Cho A;Wang Z;Gazumyan A;Cipolla M;Luchsinger L;Hillyer CD;Caskey M;Robbiani DF;Rice CM;Nussenzweig MC;Hatziioannou T;Bieniasz PD
通讯作者：
Bieniasz PD
SARS-COV-2血统的估计可传播和影响B.1.1.7在英国。
DOI：
10.1126/science.abg3055
发表时间：
2021-04-09
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Davies NG;Abbott S;Barnard RC;Jarvis CI;Kucharski AJ;Munday JD;Pearson CAB;Russell TW;Tully DC;Washburne AD;Wenseleers T;Gimma A;Waites W;Wong KLM;van Zandvoort K;Silverman JD;CMMID COVID-19 Working Group;COVID-19 Genomics UK (COG-UK) Consortium;Diaz-Ordaz K;Keogh R;Eggo RM;Funk S;Jit M;Atkins KE;Edmunds WJ
通讯作者：
Edmunds WJ
影响因子：
11.8
作者：
Laiton-Donato K;Villabona-Arenas CJ;Usme-Ciro JA;Franco-Muñoz C;Álvarez-Díaz DA;Villabona-Arenas LS;Echeverría-Londoño S;Cucunubá ZM;Franco-Sierra ND;Flórez AC;Ferro C;Ajami NJ;Walteros DM;Prieto F;Durán CA;Ospina-Martínez ML;Mercado-Reyes M
通讯作者：
Mercado-Reyes M
影响因子：
5.3
作者：
Martin DP;Murrell B;Golden M;Khoosal A;Muhire B
通讯作者：
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影响因子：
10.7
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Minh BQ