Genomic Epidemiology of Severe Acute Respiratory Syndrome Coronavirus 2, Colombia.
Genomic Epidemiology of Severe Acute Respiratory Syndrome Coronavirus 2, Colombia.
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DOI:
10.3201/eid2612.202969
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发表时间:
2020-12
影响因子:
11.8
通讯作者:
Mercado-Reyes M
中科院分区:
文献类型:
--
作者:
Laiton-Donato K;Villabona-Arenas CJ;Usme-Ciro JA;Franco-Muñoz C;Álvarez-Díaz DA;Villabona-Arenas LS;Echeverría-Londoño S;Cucunubá ZM;Franco-Sierra ND;Flórez AC;Ferro C;Ajami NJ;Walteros DM;Prieto F;Durán CA;Ospina-Martínez ML;Mercado-Reyes M
Coronavirus disease (COVID-19) in Colombia was first diagnosed in a traveler arriving from Italy on February 26, 2020. However, limited data are available on the origins and number of introductions of COVID-19 into the country. We sequenced the causative agent of COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), from 43 clinical samples we collected, along with another 79 genome sequences available from Colombia. We investigated the emergence and importation routes for SARS-CoV-2 into Colombia by using epidemiologic, historical air travel, and phylogenetic observations. Our study provides evidence of multiple introductions, mostly from Europe, and documents >12 lineages. Phylogenetic findings validate the lineage diversity, support multiple importation events, and demonstrate the evolutionary relationship of epidemiologically linked transmission chains. Our results reconstruct the early evolutionary history of SARS-CoV-2 in Colombia and highlight the advantages of genome sequencing to complement COVID-19 outbreak investigations.
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