Positron emission tomography analysis of metastatic tumor cell trafficking.
Positron emission tomography analysis of metastatic tumor cell trafficking.
复制标题
转移性肿瘤细胞运输的正电子发射断层扫描分析。
作者：
Naoto Oku;C. Koike;Masaaki Sugawara;Hideo Tsukada;Tatsuro Irimura;Shoji Okada
Organ-specific colonization of metastatic tumor cells is regulated through complex interactions of specific adhesion molecules on the tumor cell surface with organ specific microvascular endothelium. The present paper shows the real time tumor cell trafficking under the actual blood flow, which became able to be determined using a new technology, positron emission tomography. This technology would be useful to evaluate the interaction of characteristic tumor cells with various organs in vivo. High and low metastatic rat mammary adenocarcinoma cell variants, MTLn3 and MTC, respectively, were labeled with [2-18F]2-fluoro-2-deoxy-D-glucose in vitro. The labeled cells preferentially accumulated in the lungs, in which the disposition was more intense for MTLn3 than for MTC cells especially for the first 2-10 min after injection, apparently reflecting the organ specific interaction of metastatic tumor cells which may lead to metastasis. Such a short time change of cell disposition is easily determined in a living animal by this new technique. Furthermore, sialidase treatment of MTLn3 cells suppressed the accumulation of these cells in lungs, suggesting that some sialyl glycoconjugates on the MTLn3 cell surface play an important role in cell adhesion to lung endothelium. Positron emission tomography scanning thus enables the noninvasive study of the interaction of characteristic tumor cells with specific endothelium in a living animal.
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DOI：
10.1093/jnci/68.3.507
发表时间：
1982-03
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
A. Neri;D. Welch;T. Kawaguchi;G. Nicolson
通讯作者：
A. Neri;D. Welch;T. Kawaguchi;G. Nicolson
用于评估心脏 PET 研究的自动分析程序：使用氮-13-氨检测和定位冠状动脉疾病的初步结果。
DOI：
--
发表时间：
1993
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Laubenbacher,C;Rothley,J;Sitomer,J;Beanlands,R;Sawada,S;Sutor,R;Muller,D;Schwaiger,M
通讯作者：
Schwaiger,M
人类结肠癌亚系中 E-选择素依赖性粘附效率的差异表现出不同的转移潜力。
DOI：
--
发表时间：
1994
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Sawada,R;Tsuboi,S;Fukuda,M
通讯作者：
Fukuda,M
影响因子：
56.9
作者：
RICE, GE;BEVILACQUA, MP
通讯作者：
BEVILACQUA, MP
原发性和转移性黑色素瘤病变中细胞间粘附分子1的差异表达。
影响因子：
11.2
作者：
Natali,P;Nicotra,MR;Cavaliere,R;Bigotti,A;Romano,G;Temponi,M;Ferrone,S
通讯作者：
Ferrone,S