Myelitis associated with atopic disorders in Japan: a retrospective clinical study of the past 20 years.
Myelitis associated with atopic disorders in Japan: a retrospective clinical study of the past 20 years.
复制标题
日本与特应性疾病相关的脊髓炎：过去 20 年的回顾性临床研究。
作者：
J. Kira;I. Horiuchi;J. Suzuki;M. Osoegawa;S. Tobimatsu;H. Murai;M. Minohara;M. Furue;H. Ochi
目的
阐明日本患者中与特应性疾病相关的近视的临床特征。
受试者和方法
我们回顾性研究了68例连续的急性或亚急性发病的肌病诊断在九州大学医院在过去的20年中的临床，免疫学和电生理特征。
结果
在1979年至1993年诊断的28例肌萎缩症患者中，只有2例（7%）患有特应性皮炎（AD）或支气管哮喘（BA），而在1994年至1998年诊断的40例肌萎缩症患者中，有19例（48%）患有特应性皮炎或支气管哮喘。在1994年至1998年间诊断出的40例脊髓炎患者中，19例AD或BA患者以及21例无任何疾病的患者与82名健康对照相比，血清总IgE水平显着较高，高IgEaemia频率较高，螨抗原特异性IgE频率较高。表现为四肢持续性感觉异常/感觉迟钝的AD患者MRI显示颈髓病变，上肢运动诱发电位异常，但脑脊液（CSF）无异常，而BA患者的临床和肌电图显示优先累及下运动神经元。此外，12例有高IgE血症和螨抗原特异性IgE但既无AD也无BA的肌萎缩症患者表现为不完全的横肌萎缩，伴有轻度运动障碍和少数CSF异常。
结论
与特应性疾病相关的近视的临床特征部分由先前的特应性疾病的类型来区分，并且也不同于那些没有先前的特应性疾病的高IgE血症性近视。
OBJECTIVE
To clarify the clinical features of myelitis associated with atopic disorders in Japanese patients.
SUBJECTS AND METHODS
We retrospectively studied the clinical, immunological and electrophysiological features of 68 consecutive patients with myelitis of acute or subacute onset diagnosed at Kyushu University Hospital during the past 20 years.
RESULTS
While only 2 of 28 (7%) patients with myelitis diagnosed between 1979 and 1993 had either atopic dermatitis (AD) or bronchial asthma (BA), 19 of 40 (48%) patients with myelitis diagnosed between 1994 and 1998 did. Among the 40 patients with myelitis diagnosed between 1994 and 1998, 19 patients with either AD or BA as well as 21 patients without either disease showed a significantly higher level of serum total IgE, higher frequency of hyperIgEaemia and higher frequency of mite antigen-specific IgE than 82 healthy controls. Myelitis patients with AD presenting as persistent paresthesia/dysesthesia in all four limbs showed cervical cord lesions on MRI and abnormalities in upper limb motor evoked potentials but no abnormalities in the cerebrospinal fluid (CSF), while myelitis patients with BA showed preferential involvement of the lower motor neurons clinically and electromyographically. In addition, 12 patients with myelitis who had hyperIgEaemia and mite antigen-specific IgE but neither AD nor BA showed incomplete transverse myelitis with mild motor disability and few CSF abnormalities.
CONCLUSION
The clinical features of myelitis associated with atopic disorders were in part distinguished by the type of preceding atopic disorder, and also were different from those of hyperIgEaemic myelitis with no preceding atopic disorders.
DOI：
10.1016/0167-5699(94)90173-2
发表时间：
1994-08-01
期刊：
IMMUNOLOGY TODAY
影响因子：
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作者：
MILLER, SD;KARPUS, WJ
通讯作者：
KARPUS, WJ