Plasma Ceramide Concentrations in Full-Term Pregnancies Complicated with Gestational Diabetes Mellitus: A Case-Control Study.
Plasma Ceramide Concentrations in Full-Term Pregnancies Complicated with Gestational Diabetes Mellitus: A Case-Control Study.
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DOI：
10.3390/metabo12111123
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发表时间：
2022-11-16
期刊：
影响因子：
4.1
通讯作者：
中科院分区：
文献类型：
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作者：
神经酰胺是一种鞘脂，在细胞分化、增殖、凋亡和衰老中充当信使，与心血管疾病和2型糖尿病相关。神经酰胺类药物与妊娠期糖尿病（GDM）相关的证据很少。本病例对照研究旨在比较GDM妇女与健康孕妇分娩时血浆神经酰胺浓度。92名孕妇被纳入本病例对照研究，GDM组29名，对照组63名。所有妇女都被送往三级学术医院进行足月分娩。采用液相色谱-串联质谱法（LC-MS/MS）测定血浆样品中的4种分子神经酰胺，即Cer d18：1/16：0（Cer 16：0）、Cer d18：1/18：0（Cer 18：0）、Cer d18：1/24：0（Cer 24：0）和Cer d18：1/24：1（Cer 24：1）。使用Analyst SCIEX（AB Sciex Pte.有限公司、USA）。在单变量统计分析中，GDM组中的Cer 24：0浓度显著低于对照组（p = 0.01）。目前的研究表明，较低的铈24：0浓度在妊娠合并GDM。需要进一步的前瞻性研究来增强本研究的结果。
Ceramides, a sphingolipid group that acts as a messenger in cellular differentiation, proliferation, apoptosis and senescence, have been associated with cardiovascular disease and type 2 diabetes. The evidence for an association between ceramides and gestational diabetes mellitus (GDM) is scarce. This case-control study aimed to compare women with GDM with healthy, pregnant women in terms of plasma ceramide concentrations at the time of delivery. Ninety-two pregnant women were included in this case-control study, 29 in the GDM group and 63 in the control group. All women were admitted to a tertiary academic hospital for a full-term delivery. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was applied for the quantification of four molecular ceramides, namely Cer d18:1/16:0 (Cer16:0), Cer d18:1/18:0 (Cer18:0), Cer d18:1/24:0 (Cer24:0) and Cer d18:1/24:1 (Cer24:1) in plasma samples. The raw chromatographic data obtained from the LC-MS/MS analysis were processed using Analyst SCIEX (AB Sciex Pte. Ltd., USA). In a univariate statistical analysis, Cer24:0 concentration was significantly lower in the GDM group compared with the control group (p = 0.01). The present study demonstrated lower Cer24:0 concentrations in pregnancies complicated by GDM. Further prospective studies are required to enhance the results of this study.
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DOI：
10.1016/j.jchromb.2021.122734
发表时间：
2021-05-12
影响因子：
3
作者：
Begou, Olga Angeliki;Deda, Olga;Gika, Helen G.
通讯作者：
Gika, Helen G.
影响因子：
5.6
作者：
Del Gaudio, Ilaria;Sasset, Linda;Wadsack, Christian
通讯作者：
Wadsack, Christian
影响因子：
8.2
作者：
Neeland IJ;Singh S;McGuire DK;Vega GL;Roddy T;Reilly DF;Castro-Perez J;Kozlitina J;Scherer PE
通讯作者：
Scherer PE
影响因子：
13.3
作者：
Melland-Smith, Megan;Ermini, Leonardo;Caniggia, Isabella
通讯作者：
Caniggia, Isabella
DOI：
10.1159/000439413
发表时间：
2016-01-01
期刊：
NOVELTIES IN DIABETES
影响因子：
--
作者：
Spaight, Caroline;Gross, Justine;Puder, Jardena Jacqueline
通讯作者：
Puder, Jardena Jacqueline