Population-wide principal component-based quantification of blood-brain-barrier dynamics in multiple sclerosis.
Population-wide principal component-based quantification of blood-brain-barrier dynamics in multiple sclerosis.
复制标题
多发性硬化症中基于人群主成分的血脑屏障动力学定量。
DOI：
10.1016/j.neuroimage.2011.05.038
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发表时间：
2011-08-15
期刊：
影响因子：
5.7
通讯作者：
Reich, Daniel S.
中科院分区：
文献类型：
--
作者：
Shinohara, Russell T.;Crainiceanu, Ciprian M.;Caffo, Brian S.;Gaitan, Maria Ines;Reich, Daniel S.
关键词：
多发性硬化症 (MS) 中新的白质病变形成的过程目前尚不完全清楚。这种理解大部分是通过人脑的磁共振成像（MRI）得出的。 MS 中新病变发展的标志之一是静脉注射钆造影剂后 T1 加权 MRI 扫描增强，缩短了组织的纵向弛豫时间。 MRI 中的可见增强是血脑屏障打开的结果，并揭示了活动性炎症区域。现有增强病灶的发生率和数量是多发性硬化症治疗临床试验中常用的结果衡量标准。动态对比增强 MRI (DCE-MRI) 可以估计对比剂从血浆传递到 MS 病变的速率。在本文中，我们开发了一个基于主成分的框架来分析这些数据，该框架提供了新的多发性硬化症病变中血脑屏障开放的具有生物学意义的量化。为了实现这一目标，我们使用功能主成分分析来研究受试者内部和跨受试者体素水平时间序列强度的变化方向。该分析揭示并允许量化急性多发性硬化症病变中的典型时空增强模式，提供幅度、速率、形状（环状与结节状）和动力学（离心与向心）的测量。在 10 名患有复发缓解型和原发进展型多发性硬化症的受试者中，我们发现受试者有 0 到 12 个钆增强病灶，其中大多数为向心性增强。我们使用新颖的措施量化了每个病变内的时空行为。这些技术的进一步应用将确定这些病变测量可以在多大程度上预测或跟踪对该疾病的治疗或长期预后的反应。
The processes by which new white-matter lesions in multiple sclerosis (MS) develop are only partially understood. Much of this understanding has come through magnetic resonance imaging (MRI) of the human brain. One of the hallmarks of new lesion development in MS is enhancement on T1-weighted MRI scans following the intravenous administration of a gadolinium-based contrast agent that shortens the longitudinal relaxation time of the tissue. Visible enhancement in the MRI results from the opening of the blood-brain barrier and reveals areas of active inflammation. The incidence and number of existing enhancing lesions are common outcome measures used in MS treatment clinical trials. Dynamic-contrast-enhanced MRI (DCE-MRI) can estimate the rate at which contrast agents pass from the plasma to MS lesions. In this paper, we develop a principal component-based framework for the analysis of these data that provides biologically meaningful quantification of blood-brain barrier opening in new MS lesions. To accomplish this, we use functional principal components analysis to study directions of variation in the voxel-level time series of intensities both within and across subjects. The analysis reveals and allows quantification of typical spatiotemporal enhancement patterns in acute MS lesions, providing measures of magnitude, rate, shape (ring-like vs. nodular), and dynamics (centrifugal vs. centripetal). Across 10 subjects with relapsing-remitting and primary progressive MS, we found subjects to have between 0 and 12 gadolinium-enhancing lesions, the majority of which enhanced centripetally. We quantified the spatiotemporal behavior within each of these lesion using novel measures. Further application of these techniques will determine the extent to which these lesion measures can predict or track response to therapy or long-term prognosis in this disorder.
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影响因子：
11.2
作者：
Gaitan, Maria I.;Shea, Colin D.;Evangelou, Iordanis E.;Stone, Roger D.;Fenton, Kaylan M.;Bielekova, Bibiana;Massacesi, Luca;Reich, Daniel S.
通讯作者：
Reich, Daniel S.
影响因子：
1.1
作者：
Greven S;Crainiceanu C;Caffo B;Reich D
通讯作者：
Reich D
影响因子：
9.9
作者：
KERMODE, AG;TOFTS, PS;MCDONALD, WI
通讯作者：
MCDONALD, WI
影响因子：
1.8
作者：
Di, Chong-Zhi;Crainiceanu, Ciprian M.;Punjabi, Naresh M.
通讯作者：
Punjabi, Naresh M.
影响因子：
5.7
作者：
Shiee, Navid;Bazin, Pierre-Louis;Ozturk, Arzu;Reich, Daniel S.;Calabresi, Peter A.;Pham, Dzung L.
通讯作者：
Pham, Dzung L.