Crystal identification in positron emission tomography using nonrigid registration to a Fourier-based template.
Crystal identification in positron emission tomography using nonrigid registration to a Fourier-based template.
复制标题
DOI：
10.1088/0031-9155/53/18/011
复制
发表时间：
2008-09-21
影响因子：
3.5
通讯作者：
Badawi RD
中科院分区：
文献类型：
--
作者：
Chaudhari AJ;Joshi AA;Bowen SL;Leahy RM;Cherry SR;Badawi RD
现代正电子发射断层扫描（PET）探测器通常由闪烁晶体的2D模块化阵列制成。它们的特征泛场响应（或泛场直方图）必须被分割，以便正确地确定系统中湮灭光子相互作用的晶体。因此产生的晶体识别信息也需要精确的系统建模以及详细的检测器表征和性能研究。在本文中，我们提出了一个半自动的通用模板引导计划分割洪水直方图。我们首先生成一个模板图像，利用傅立叶空间分析在给定的洪水直方图的空间频率信息。该模板图像是洪水直方图的低阶近似，并且可以用在直方图中相邻峰之间的中间绘制的水平线和垂直线进行分割。然后，通过能够迭代地最小化强度差的基于同态多项式的翘曲方案将模板注册到给定的洪水直方图。由此计算的位移场被应用于模板的分割，从而导致给定洪水直方图的分割。我们评估我们的分割方案的光电倍增管为基础的PET探测器，一个探测器与读出的位置敏感的雪崩光电二极管（PSAPD）和探测器组成的光电倍增管和闪烁体阵列的堆栈。此外，我们定量地比较所提出的方法的性能的手动分割方案，使用重建图像的线源幻影。我们还提出了一种自适应的方法，减少失真的洪水直方图获得PET探测器，使用PSAPD。
Modern Positron Emission Tomography (PET) detectors typically are made from 2D modular arrays of scintillation crystals. Their characteristic flood field response (or flood histogram) must be segmented in order to correctly determine the crystal of annihilation photon interaction in the system. Crystal identification information thus generated is also needed for accurate system modeling as well as for detailed detector characterization and performance studies. In this paper, we present a semi-automatic general purpose template-guided scheme for segmentation of flood histograms. We first generate a template image that exploits the spatial frequency information in the given flood histogram using Fourier-space analysis. This template image is a lower order approximation of the flood histogram, and can be segmented with horizontal and vertical lines drawn midway between adjacent peaks in the histogram. The template is then registered to the given flood histogram by a diffeomorphic polynomial-based warping scheme that is capable of iteratively minimizing intensity differences. The displacement field thus calculated is applied to the segmentation of the template resulting in a segmentation of the given flood histogram. We evaluate our segmentation scheme for a photomultiplier tube-based PET detector, a detector with readout by a position-sensitive avalanche photodiode (PSAPD) and a detector consisting of a stack of photomultiplier tubes and scintillator arrays. Further, we quantitatively compare the performance of the proposed method to that of a manual segmentation scheme using reconstructed images of a line source phantom. We also present an adaptive method for distortion reduction in flood histograms obtained for PET detectors that use PSAPDs.
登录
查看更多内容
影响因子：
1.8
作者：
Chaudhari, Abhijit J.;Yang, Yongfeng;Badawi, Ramsey D.
通讯作者：
Badawi, Ramsey D.
影响因子：
0.6
作者：
ARMIJO, L
通讯作者：
ARMIJO, L
影响因子：
1.8
作者：
Doshi, NK;Silverman, RW;Cherry, SR
通讯作者：
Cherry, SR
影响因子：
10.6
作者：
CUTLER, PD;HOFFMAN, EJ
通讯作者：
HOFFMAN, EJ
影响因子：
1.1
作者：
Lazzerini, B;Marcelloni, F;Marola, G
通讯作者：
Marola, G