MiR-424/503-mediated Rictor upregulation promotes tumor progression.
MiR-424/503-mediated Rictor upregulation promotes tumor progression.
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DOI：
10.1371/journal.pone.0080300
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Okada M
中科院分区：
文献类型：
--
作者：
Oneyama C;Kito Y;Asai R;Ikeda J;Yoshida T;Okuzaki D;Kokuda R;Kakumoto K;Takayama K;Inoue S;Morii E;Okada M
mTOR复合物2（mTORC 2）信号传导在多种类型的人类癌症中上调，但其激活和调节的分子机制仍然难以捉摸。在这里，我们发现microRNA介导的Rictor（一种mTORC 2特异性成分）上调有助于肿瘤进展。Rictor通过在具有c-Src上调的人前列腺癌和结肠癌细胞系中以及在Src转化的细胞中抑制miR-424/503簇而上调。这些细胞的致瘤性和侵袭活性通过miR-424/503的再表达而被抑制。Rictor上调促进mTORC 2的形成并诱导mTORC 2的活化，导致促进肿瘤生长和侵袭。此外，miR-424/503的下调与结肠癌组织中的Rictor上调相关。这些发现表明miR-424/503-Rictor通路在肿瘤进展中起着至关重要的作用。
mTOR complex 2 (mTORC2) signaling is upregulated in multiple types of human cancer, but the molecular mechanisms underlying its activation and regulation remain elusive. Here, we show that microRNA-mediated upregulation of Rictor, an mTORC2-specific component, contributes to tumor progression. Rictor is upregulated via the repression of the miR-424/503 cluster in human prostate and colon cancer cell lines that harbor c-Src upregulation and in Src-transformed cells. The tumorigenicity and invasive activity of these cells were suppressed by re-expression of miR-424/503. Rictor upregulation promotes formation of mTORC2 and induces activation of mTORC2, resulting in promotion of tumor growth and invasion. Furthermore, downregulation of miR-424/503 is associated with Rictor upregulation in colon cancer tissues. These findings suggest that the miR-424/503–Rictor pathway plays a crucial role in tumor progression.
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影响因子：
16
作者：
Loewith, R;Jacinto, E;Hall, MN
通讯作者：
Hall, MN
影响因子：
--
作者：
Nagaraja, Ankur K.;Creighton, Chad J.;Matzuk, Martin M.
通讯作者：
Matzuk, Martin M.
影响因子：
8.8
作者：
Petroulakis, E;Mamane, Y;Le Bacquer, O;Shahbazian, D;Sonenberg, N
通讯作者：
Sonenberg, N
影响因子：
11.2
作者：
Doghman M;El Wakil A;Cardinaud B;Thomas E;Wang J;Zhao W;Peralta-Del Valle MH;Figueiredo BC;Zambetti GP;Lalli E
通讯作者：
Lalli E
影响因子：
7.5
作者：
Dazert, Eva;Hall, Michael N.
通讯作者：
Hall, Michael N.