Discovery of blood transcriptomic markers for depression in animal models and pilot validation in subjects with early-onset major depression.
Discovery of blood transcriptomic markers for depression in animal models and pilot validation in subjects with early-onset major depression.
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DOI：
10.1038/tp.2012.26
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发表时间：
2012-04-17
影响因子：
6.8
通讯作者：
Redei EE
中科院分区：
文献类型：
--
作者：
Pajer K;Andrus BM;Gardner W;Lourie A;Strange B;Campo J;Bridge J;Blizinsky K;Dennis K;Vedell P;Churchill GA;Redei EE
早发性重度抑郁障碍(MDD)是一种严重且流行于青少年和青壮年的精神疾病。目前的治疗方法并不是最有效的。早发性MDD的生物标志物可以提高诊断的特异性，但不存在这样的生物标志物。我们发现早发性MDD生物标记物的创新方法结合了两个抑郁症动物模型血液中全基因组转录图谱的结果，代表了MDD的遗传和环境、应激相关的病因。我们对这组26个候选血液转录标记物的组合进行了无偏见的分析，样本为15-19岁的MDD患者(N=14)和非疾病患者(ND，N=14)。由11个血液标志物组成的小组将早发性MDD患者与ND组区分开来。此外，一个单独但部分重叠的18个转录小组区分了患有或不伴有焦虑的MDD受试者。在慢性应激动物模型中发现的四个转录本与青少年的虐待得分相关。这些试点数据表明，我们的方法可以产生临床上有效的早发性MDD血液转录本诊断小组，这可以减少这一人群的诊断异质性，并有可能推进个性化治疗策略。
Early-onset major depressive disorder (MDD) is a serious and prevalent psychiatric illness in adolescents and young adults. Current treatments are not optimally effective. Biological markers of early-onset MDD could increase diagnostic specificity, but no such biomarker exists. Our innovative approach to biomarker discovery for early-onset MDD combined results from genome-wide transcriptomic profiles in the blood of two animal models of depression, representing the genetic and the environmental, stress-related, etiology of MDD. We carried out unbiased analyses of this combined set of 26 candidate blood transcriptomic markers in a sample of 15–19-year-old subjects with MDD (N=14) and subjects with no disorder (ND, N=14). A panel of 11 blood markers differentiated participants with early-onset MDD from the ND group. Additionally, a separate but partially overlapping panel of 18 transcripts distinguished subjects with MDD with or without comorbid anxiety. Four transcripts, discovered from the chronic stress animal model, correlated with maltreatment scores in youths. These pilot data suggest that our approach can lead to clinically valid diagnostic panels of blood transcripts for early-onset MDD, which could reduce diagnostic heterogeneity in this population and has the potential to advance individualized treatment strategies.
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影响因子：
56.9
作者：
Biederer, T;Sara, Y;Südhof, TC
通讯作者：
Südhof, TC
影响因子：
3.7
作者：
Domenici E;Willé DR;Tozzi F;Prokopenko I;Miller S;McKeown A;Brittain C;Rujescu D;Giegling I;Turck CW;Holsboer F;Bullmore ET;Middleton L;Merlo-Pich E;Alexander RC;Muglia P
通讯作者：
Muglia P
影响因子：
7.6
作者：
Keenan-Miller, Danielle;Hammen, Constance L.;Brennan, Patricia A.
通讯作者：
Brennan, Patricia A.
影响因子：
6.7
作者：
Kendler, K. S.;Gatz, M.;Pedersen, N. L.
通讯作者：
Pedersen, N. L.
影响因子：
2.1
作者：
Irizarry, RA;Hobbs, B;Speed, TP
通讯作者：
Speed, TP