The Autophagy Database: an all-inclusive information resource on autophagy that provides nourishment for research.
The Autophagy Database: an all-inclusive information resource on autophagy that provides nourishment for research.
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DOI：
10.1093/nar/gkq995
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发表时间：
2011-01
影响因子：
14.9
通讯作者：
Sugawara H
中科院分区：
文献类型：
--
作者：
Homma K;Suzuki K;Sugawara H
自噬是一种在真核生物中普遍观察到的自我消化过程，并已被证明在饥饿和清除有害物质的生存中起着至关重要的作用。尽管已经取得了很大的进展，但自噬机制中的许多问题仍然没有解决。由于在每个物种中都发现了大量与自噬相关的蛋白质，因此收集数据，识别其他物种中的同源物并使其可用的数据库将有助于研究进展。由于没有这样的资源存在，我们建立了自噬数据库（http：//tp-apg.genes.nig.ac.jp/autophagy），以提供基础知识，相关文献的最新信息，以及41种真核生物中自噬相关蛋白及其同源物的列表。从数据库中，用户可以通过关键字或序列搜索蛋白质，以获得丰富的数据，包括功能和结构信息，并找到其功能已在其他物种中证明的蛋白质的可能功能同源物。作为结合磷脂的蛋白质，磷脂酰肌醇3-磷酸（PI 3 P）对于自噬的进行是必不可少的，我们进行了原始分析以鉴定可能的PI 3 P结合蛋白，并从数据库中获得列表。该数据库有望通过提供有关该主题的基础和专业数据，推动对自噬的进一步研究。
Autophagy is a process of self-digestion generally observed in eukaryotes and has been shown to play crucial roles for survival under starvation and removal of deleterious substances. Despite great advances that have been made, many problems in mechanisms of autophagy remain unsolved. As a large number of autophagy-related proteins are identified in each species, a database that collects data, identifies their homologs in other species and makes them available will contribute to research advancement. As no such resources exist, we built the Autophagy database (http://tp-apg.genes.nig.ac.jp/autophagy) to provide basics, up-to-date information on relevant literature, and a list of autophagy-related proteins and their homologs in 41 eukaryotes. From the database, the user can search for proteins by keywords or sequences to obtain a wealth of data including functional and structural information and find possible functional homologs of proteins whose functions have been demonstrated in other species. As proteins that bind the phospholipid, phosphatidyl inositol 3-phosphate (PI3P) are essential for autophagy to proceed, we carried out an original analysis to identify probable PI3P-binding proteins, and made the list available from the database. The database is expected to give impetus to further research on autophagy by providing basic and specialized data on the subject.
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影响因子：
13.3
作者：
Meijer, Wiebe H.;van der Klei, Ida J.;Kiel, Jan A. K. W.
通讯作者：
Kiel, Jan A. K. W.
影响因子：
4.8
作者：
Watanabe, Yasunori;Noda, Nobuo N.;Inagaki, Fuyuhiko
通讯作者：
Inagaki, Fuyuhiko
影响因子：
64.5
作者：
Hailey DW;Rambold AS;Satpute-Krishnan P;Mitra K;Sougrat R;Kim PK;Lippincott-Schwartz J
通讯作者：
Lippincott-Schwartz J
影响因子：
--
作者：
Fukuchi, Satoshi;Homma, Keiichi;Nishikawa, Ken
通讯作者：
Nishikawa, Ken
影响因子：
4.8
作者：
Yamaguchi, Masaya;Noda, Nobuo N.;Inagaki, Fuyuhiko
通讯作者：
Inagaki, Fuyuhiko