Association between timing and consistency of physical activity and type 2 diabetes: a cohort study on participants of the UK Biobank.
Association between timing and consistency of physical activity and type 2 diabetes: a cohort study on participants of the UK Biobank.
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DOI：
10.1007/s00125-023-06001-7
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发表时间：
2023-12
期刊：
影响因子：
8.2
通讯作者：
Patel, Chirag J.
中科院分区：
文献类型：
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作者：
Tian, Caiwei;Buerki, Charlyne;Westerman, Kenneth E.;Patel, Chirag J.
我们试图量化早上、下午或晚上的体育活动与一致性（如常规）和2型糖尿病风险之间的关系。一组93095名英国生物银行参与者（平均年龄62岁）无2型糖尿病史，佩戴腕带加速度计1周。我们将加速度计信息转换为估算代谢当量任务（MET），将白天三个时间段（上午、下午和晚上）内完成的总体力活动的MET h相加。我们将体力活动一致性量化为参与者每日总体力活动的标准差。我们最终将以下每项与2型糖尿病事件联系起来：(1)每周早上、下午或晚上“分段”的MET小时；(2)一致性。我们还考虑了中高强度体力活动（MVPA）和高强度体力活动（VPA）与2型糖尿病发病率的关系。当将MET作为体力活动指标时，我们观察到早上（HR 0.90 [95% CI 0.86, 0.93], p=7×10−8）和下午（HR 0.91 [95% CI 0.87, 0.95], p=1×10−5）与2型糖尿病的保护性关联，但没有证据表明晚上体力活动（HR 0.95 [95% CI 0.90, 1.00], p=0.07）与2型糖尿病有关联。met测量的上午和下午的体力活动没有差异。我们的替代模型强调了调整生活方式因素（如睡眠时间和饮食）的重要性；在调整生活方式变量后，下午和晚上体力活动之间的替代效应减弱。met测量的身体活动的一致性与2型糖尿病无关（p=0.07）。MVPA和VPA在一天中的任何时候都与2型糖尿病的风险降低有关。上午和下午的身体活动的总代谢当量对糖尿病风险有保护作用，而晚上的活动与糖尿病无关。持续的体育锻炼对降低患糖尿病的风险没有作用。剧烈运动与较低的风险相关，无论在一天中的什么时间进行。在线版本包含同行评审但未经编辑的补充材料，可在10.1007/s00125-023-06001-7获得。
We sought to quantify the relationship between morning, afternoon or evening physical activity and consistency (e.g. routine) and risk of type 2 diabetes. A cohort of 93,095 UK Biobank participants (mean age 62 years) without a history of type 2 diabetes wore a wrist-worn accelerometer for 1 week. We converted accelerometer information to estimate metabolic equivalent of task (MET), summing MET h of total physical activity completed within three intra-day time segments (morning, afternoon and evening). We quantified physical activity consistency as the SD of participants’ daily total physical activity. We ultimately associated each of the following with incident type 2 diabetes: (1) morning, afternoon or evening ‘time-segmented’ MET h per week; and (2) consistency. We also considered moderate-to-vigorous physical activity (MVPA) and vigorous physical activity (VPA) in association with type 2 diabetes incidence. When considering MET as the physical activity measure, we observed protective associations of morning (HR 0.90 [95% CI 0.86, 0.93], p=7×10−8) and afternoon (HR 0.91 [95% CI 0.87, 0.95], p=1×10−5) but did not have evidence for evening physical activity (HR 0.95 [95% CI 0.90, 1.00], p=0.07) with type 2 diabetes. There was no difference between MET-measured morning and afternoon physical activity. Our substitution model highlighted the importance of adjusting for lifestyle factors (e.g. sleep time and diet); the effect of a substitution between afternoon and evening physical activity was attenuated after adjustment for lifestyle variables. Consistency of MET-measured physical activity was not associated with type 2 diabetes (p=0.07). MVPA and VPA were associated with decreased risk for type 2 diabetes at all times of the day. Total metabolic equivalents of physical activity in the morning and afternoon had a protective effect on diabetes risk and evening activity was not associated with diabetes. Consistency of physical activity did not play a role in decreasing risk for diabetes. Vigorous activity is associated with lower risk no matter the time of day of activity. The online version contains peer-reviewed but unedited supplementary material available at 10.1007/s00125-023-06001-7.
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