Prenatal treatment with glucocorticoids sensitizes the hpa axis response to stress among full-term infants.
Prenatal treatment with glucocorticoids sensitizes the hpa axis response to stress among full-term infants.
复制标题
DOI：
10.1002/dev.20510
复制
发表时间：
2011-03
影响因子：
2.2
通讯作者：
中科院分区：
文献类型：
--
作者：
本研究的目的是确定健康足月新生儿产前治疗合成糖皮质激素（GC）的HPA轴功能的后果，这是先兆早产的常规治疗。将90名足月婴儿招募到两个研究组中（30名接受贝伐他汀治疗; 60名对照组在出生时和性别上匹配GA）。皮质醇和行为反应的痛苦压力的脚跟坚持抽血出生后24小时进行了评估。尽管基线水平没有差异，但接受产前激素治疗的足月婴儿对足跟棒治疗的皮质醇反应更大。此外，在推荐的倍他米松给药时间窗（24-34孕周）内，妊娠早期暴露于倍他米松的婴儿对足跟棒的皮质醇反应最大。这些数据增加了越来越多的证据表明，产前暴露于升高的GC程序的HPA轴的发展。
The objective of this study was to determine the consequences for HPA axis functioning among healthy full-term newborns of prenatal treatment with the synthetic glucocorticoid (GC), betamethasone, which is the routine treatment for threatened preterm delivery. Ninety full-term infants were recruited into two study groups (30 betamethasone treated; 60 comparison group matched for GA at birth and sex). The cortisol and behavioral response to the painful stress of a heel-stick blood draw was assessed 24 hr after birth. Full-term infants exposed to prenatal betamethasone displayed a larger cortisol response to the heel-stick procedure, despite no differences in baseline levels. Further, within the recommended window of betamethasone administration (24–34 gestational weeks), infants exposed to betamethasone earlier in gestation displayed the largest cortisol response to the heel-stick. These data add to accumulating evidence that prenatal exposure to elevated GCs programs the development of the HPA axis.
登录
查看更多内容
影响因子：
2.9
作者：
Davis, E. P.;Townsend, E. L.;Georgieff, M. K.
通讯作者：
Georgieff, M. K.
影响因子：
5.8
作者：
Hirvikoski, Tatja;Nordenstrom, Anna;Lajic, Svetlana
通讯作者：
Lajic, Svetlana
影响因子：
4
作者：
Buss, KA;Davidson, RJ;Goldsmith, HH
通讯作者：
Goldsmith, HH
影响因子：
5.8
作者：
Kajantie, E;Raivio, T;Andersson, S
通讯作者：
Andersson, S
影响因子：
7.4
作者：
Grunau, RE;Holsti, L;Yu, W
通讯作者：
Yu, W