Neuropeptide Y expression and endogenous leptin concentrations in a dietary model of obesity.
Neuropeptide Y expression and endogenous leptin concentrations in a dietary model of obesity.
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肥胖饮食模型中神经肽 Y 的表达和内源性瘦素浓度。
DOI：
10.1002/j.1550-8528.1999.tb00439.x
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Lee,J
中科院分区：
文献类型：
--
作者：
Lauterio,TJ;Davies,MJ;DeAngelo,M;Peyser,M;Lee,J
托马斯·劳特里奥Michael J. Davies，Mark Deangelo，Michael Peyser，AND James Lee. Neuropeptide Y expression and endogenous leptin concentrations in a dietary model of obesity.Obes Res.Obes Res.Objective：To determine how leptin concentrations and neuropeptide（NPY）are regulated in a model of dietary obesity relating to relative growth（RG）and relative food consumption（RFC）.Research Methods and Procedures：对Sprague-Dawley大鼠喂食中等高脂肪饮食14周，在此期间，动物分为肥胖倾向（OP）和肥胖抵抗（OR）群体。每周计算RG率和RFC。研究后，肥胖指数计算和弓状核（ARC）NPY的表达测定原位杂交（ISH）或核糖核酸酶保护（RPA）assays.Results：体重更大的OP大鼠2周后的饮食相比，OR大鼠，并保持不同的整个研究。仅在研究的前2周内，OP大鼠的RG和RFC大于OR大鼠。在实验过程中，两组大鼠的瘦素浓度均升高，但OP大鼠的升高幅度大于OR大鼠。胰岛素的变化大于瘦素的变化。ARC神经肽Y mRNA的表达是没有不同的OP和OR大鼠之间的ISH和RPA.Discussion测量：虽然NPY的表达已被报道是不同的OP和OR大鼠最初，这种差异消散体重的分歧。RFC和RG数据表明，在饮食的前2周内，初始NPY升高可能有助于OP大鼠体重增加。OP大鼠中较高的相对瘦素浓度可能是使OP大鼠肥胖和表观瘦素和胰岛素抵抗的差异正常化所必需的。
LAUTERIO, THOMAS J., MICHAEL J. DAVIES, MARK DEANGELO, MICHAEL PEYSER, AND JAMES LEE. Neuropeptide Y expression and endogenous leptin concentrations in a dietary model of obesity.Obes Res.Objective: To determine how leptin concentrations and neuropeptide (NPY) are regulated in a model of dietary obesity in relation to relative growth (RG) and relative food consumption (RFC).Research Methods and Procedures: Sprague—Dawley rats were fed a moderately high‐fat diet for 14 weeks over which time animals diverged into obesity‐prone (OP) and obesity‐resistant (OR) populations. RG rates and RFC were calculated weekly. Following the study, an adiposity index was calculated and arcuate nucleus (ARC) NPY expression was determined by in situ hybridization (ISH) or ribonuclease protection (RPA) assays.Results: Body weights were greater in OP rats after 2 weeks on the diet compared to OR rats and remained different throughout the study. RG and RFC were greater in OP rats compared to OR rats only during the first 2 weeks of the study. Leptin concentrations rose in both groups during the experiment, but the increase was greater in OP rats than in OR rats. Insulin changes paralleled those for leptin. ARC NPY mRNA expression was not different between OP and OR rats as measured by ISH and RPA.Discussion: Although NPY expression has been reported to be different initially in OP and OR rats, this difference dissipates following divergence of body weight. RFC and RG data suggest the initial NPY elevation may contribute to increased weight gain of OP rats during the first 2 weeks of the diet. Higher relative leptin concentrations in OP rats may be necessary to normalize differences in adiposity and apparent leptin and insulin resistance of OP rats.
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影响因子：
3.5
作者：
Mercer, JG;Moar, KM;Hoggard, N
通讯作者：
Hoggard, N
影响因子：
15.9
作者：
Schwartz, MW;Seeley, RJ;Baskin, DG
通讯作者：
Baskin, DG
瘦素是自发性搏动生长激素 (GH) 分泌和 GH 对 GH 释放激素反应的有效刺激剂*
影响因子：
5
作者：
G. Tannenbaum;W. Gurd;M. Lapointe
通讯作者：
M. Lapointe
纯化饮食的开发和表征，以识别肥胖易感和抵抗的大鼠群体。
DOI：
10.1093/jn/124.11.2172
发表时间：
1994
期刊：
The Journal of nutrition
影响因子：
--
作者：
Lauterio,TJ;Bond,JP;Ulman,EA
通讯作者：
Ulman,EA
影响因子：
4.8
作者：
M. Schwartz;A. Sipols;J. L. Marks;G. Sanacora;Jeffery D. White;A. Scheurink;S. Kahn;D. Baskin;S. Woods;D. Figlewicz
通讯作者：
M. Schwartz;A. Sipols;J. L. Marks;G. Sanacora;Jeffery D. White;A. Scheurink;S. Kahn;D. Baskin;S. Woods;D. Figlewicz