Estrogen and Androgen Blockade for Advanced Prostate Cancer in the Era of Precision Medicine.
Estrogen and Androgen Blockade for Advanced Prostate Cancer in the Era of Precision Medicine.
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DOI：
10.3390/cancers10020029
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发表时间：
2018-01-23
期刊：
影响因子：
5.2
通讯作者：
Inoue S
中科院分区：
文献类型：
--
作者：
Fujimura T;Takayama K;Takahashi S;Inoue S
雄激素剥夺治疗（ADT）已被广泛用于晚期前列腺癌（PC）患者，以通过雄激素受体（AR）和AR协同转录因子控制关键信号通路;然而，PC在ADT期间逐渐获得致死表型并导致去势抵抗性PC（CRPC）。因此，在临床实践中需要新的治疗策略。此外，AR;雌激素受体（ER; ERα和ERβ）;雌激素相关受体（ERRα、ERRβ和ERRγ）参与PC的发生和调节。近年来的研究表明，PC的相关分子如KLF 5、FOXO 1、PDGFA、VEGF-A、WNT 5A、TGFβ1和micro-RNA 135 a等通过ER和ERRs发挥作用。已经开发了选择性ER调节剂（SERM）。最近，雌激素和雄激素阻断（EAB）使用托瑞米芬和ADT的组合已被证明可以改善治疗初治骨转移性PC的生化复发率。在未来，ADT单独或EAB对个体的适用性可能会通过基于从RT-PCR、基因面板或液体活检获得的信息做出临床决策来评估，以创建“个性化医学”或“精确医学”。在这篇综述中，我们总结了ER和ERR信号通路，分子诊断，和SERMs作为候选人先进的PC治疗。
Androgen deprivation therapy (ADT) has been widely prescribed for patients with advanced prostate cancer (PC) to control key signaling pathways via androgen receptor (AR) and AR-collaborative transcriptional factors; however, PC gradually acquires a lethal phenotype and results in castration-resistant PC (CRPC) during ADT. Therefore, new therapeutic strategies are required in clinical practice. In addition, ARs; estrogen receptors (ERs; ERα and ERβ); and estrogen-related receptors (ERRs; ERRα, ERRβ, and ERRγ) have been reported to be involved in the development or regulation of PC. Recent investigations have revealed the role of associated molecules, such as KLF5, FOXO1, PDGFA, VEGF-A, WNT5A, TGFβ1, and micro-RNA 135a of PC, via ERs and ERRs. Selective ER modulators (SERMs) have been developed. Recently, estrogen and androgen blockade (EAB) using a combination of toremifene and ADT has been demonstrated to improve biochemical recurrence rate in treatment-naïve bone metastatic PC. In the future, the suitability of ADT alone or EAB for individuals may be evaluated by making clinical decisions on the basis of information obtained from RT-PCR, gene-panel, or liquid biopsy to create a “personalized medicine” or “precision medicine”. In this review, we summarize ER and ERR signaling pathways, molecular diagnosis, and SERMs as candidates for advanced PC treatment.
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影响因子：
4.8
作者：
CASTAGNETTA, LA;MICELI, MD;CARRUBA, G
通讯作者：
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影响因子：
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影响因子：
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影响因子：
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作者：
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