The association of sleep and pain: an update and a path forward.
The association of sleep and pain: an update and a path forward.
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DOI：
10.1016/j.jpain.2013.08.007
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发表时间：
2013-12
期刊：
影响因子：
4
通讯作者：
Smith, Michael T.
中科院分区：
文献类型：
--
作者：
Finan, Patrick H.;Goodin, Burel R.;Smith, Michael T.
大量证据表明，睡眠和疼痛是相关的。然而，许多问题仍然存在的因果关系的方向，在他们的协会，以及机制，可以解释他们的协会。普遍的看法是，它们是相互关联的。本综述严格审查最近的前瞻性和实验性文献（2005年至今），试图更新有关睡眠和疼痛的关联的方向性和机制的新兴主题领域。基于人群的纵向研究中出现的一个关键趋势是，睡眠障碍可以可靠地预测慢性疼痛的新事件和恶化。对疼痛和睡眠进行深入的主观和客观评估的微纵向研究支持这样一种观点，即睡眠障碍是比疼痛更强，更可靠的疼痛预测因子。最近的实验研究表明，睡眠障碍可能会损害有助于慢性疼痛的发展和维持的关键过程，包括内源性疼痛抑制和关节疼痛。几个生物心理社会的目标，为未来的机制研究睡眠和疼痛进行了讨论，包括多巴胺和阿片系统，积极和消极的影响，和社会人口因素。这篇重要的综述分析了最近关于睡眠与疼痛相关性的前瞻性和实验性研究（2005年至今），试图确定暗示方向性和潜在机制的趋势。需要对这一文献进行更新，以指导未来的临床工作，开发和加强慢性睡眠障碍和慢性疼痛的治疗。
Ample evidence suggests that sleep and pain are related. However, many questions remain about the direction of causality in their association, as well as mechanisms that may account for their association. The prevailing view has generally been that they are reciprocally related. The present review critically examines the recent prospective and experimental literature (2005-present) in an attempt to update the field on emergent themes pertaining to the directionality and mechanisms of the association of sleep and pain. A key trend emerging from population-based longitudinal studies is that sleep impairments reliably predict new incidents and exacerbations of chronic pain. Microlongitudinal studies employing deep subjective and objective assessments of pain and sleep support the notion that sleep impairments are a stronger, more reliable predictor of pain than pain is of sleep impairments. Recent experimental studies suggest that sleep disturbance may impair key processes that contribute to the development and maintenance of chronic pain, including endogenous pain inhibition and joint pain. Several biopsychosocial targets for future mechanistic research on sleep and pain are discussed, including dopamine and opioid systems, positive and negative affect, and sociodemographic factors. This critical review examines the recent prospective and experimental research (2005-present) on the association of sleep and pain in an attempt to identify trends suggestive of directionality and potential mechanisms. An update on this literature is needed to guide future clinical efforts to develop and augment treatments for chronic sleep disturbance and chronic pain.
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