Cell-mediated immune responses in tuberculosis.
Cell-mediated immune responses in tuberculosis.
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DOI：
10.1146/annurev.immunol.021908.132703
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发表时间：
2009
影响因子：
29.7
通讯作者：
Cooper AM
中科院分区：
文献类型：
--
作者：
Cooper AM
结核病主要是肺部的疾病，传播取决于这种关键器官的生产性感染。在用结核分枝杆菌（MTB）感染气溶胶后，获得的细胞免疫反应会慢慢诱导并在肺内表达。这种缓慢使感染得以建立，并迫使所获得的反应在炎症部位的背景下表达，该炎症部位已被细菌引发和调节。 MTB具有多种与先天反应相互作用以及这种相互作用以及通过多种机制对免疫反应的自动调节的各种表面分子，导致对细菌生长的最佳控制。为了改善当前的疫苗策略，我们必须了解介导肺中免疫反应的诱导，表达和调节的因素。我们还必须确定如何在不诱导免疫病理后果的情况下诱导已知和新颖的免疫保护反应。
Tuberculosis is primarily a disease of the lung and dissemination is dependent upon productive infection of this critical organ. Upon aerosol infection with Mycobacterium tuberculosis (Mtb), the acquired cellular immune response is slow to be induced and to be expressed within the lung. This slowness allows infection to become established and forces the acquired response to be expressed in a context of an inflammatory site that has been initiated and modulated by the bacterium. Mtb has a variety of surface molecules that interact with the innate response and this interaction along with the auto-regulation of the immune response by several mechanisms results in less than optimal control of bacterial growth. To improve current vaccine strategies we must understand the factors that mediate induction, expression and regulation of the immune response in the lung. We must also determine how to induce both known and novel immunoprotective responses without inducing immunopathologic consequences.
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影响因子：
4.4
作者：
Banaiee, Niaz;Kincaid, Eleanor Z.;Ernst, Joel D.
通讯作者：
Ernst, Joel D.
DOI：
10.4049/jimmunol.181.8.5545
发表时间：
2008-10-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Beamer GL;Flaherty DK;Assogba BD;Stromberg P;Gonzalez-Juarrero M;de Waal Malefyt R;Vesosky B;Turner J
通讯作者：
Turner J
DOI：
10.1084/jem.20021183
发表时间：
2002-11-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Aliberti J;Serhan C;Sher A
通讯作者：
Sher A
影响因子：
4.4
作者：
Caccamo, Nadia;Meraviglia, Serena;Salerno, Alfredo
通讯作者：
Salerno, Alfredo
影响因子：
3.1
作者：
Chackerian, AA;Perera, TV;Behar, SM
通讯作者：
Behar, SM