Triglycerides as Biomarker for Predicting Systemic Lupus Erythematosus Related Kidney Injury of Negative Proteinuria.
Triglycerides as Biomarker for Predicting Systemic Lupus Erythematosus Related Kidney Injury of Negative Proteinuria.
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DOI：
10.3390/biom12070945
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发表时间：
2022-07-05
期刊：
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
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较少的生物标志物可用于预测系统性红斑狼疮（SLE）相关的肾损伤。本文提出了一种关联规则的先验算法，用于挖掘阴性蛋白尿sle相关肾损伤的预测性生物标志物。采用关联规则的先验算法识别生物标志物，采用logistic回归分析和spearman相关分析评估甘油三酯与阴性蛋白尿sle相关性肾损伤的相关性。通过关联规则的先验算法提取甘油三酯。甘油三酯水平明显升高，是sle相关肾损伤的独立危险因素。高甘油三酯组sle相关肾损伤患者数量、SLEDAI-2K、尿P-CAST、血尿素氮、血清肌酐、蛋白尿水平升高。甘油三酯水平与蛋白尿、P-CAST呈正相关，与白蛋白、IgG呈负相关。甘油三酯和甘油三酯合并蛋白尿的ROC曲线下面积分别为0.72和0.82。值得注意的是，50%的sle相关的蛋白尿阴性肾损伤可以通过高甘油三酯水平来识别。高甘油三酯水平出现在肾损伤开始时，与肾小球滤过率相反。甘油三酯可能是预测sled相关肾损伤的潜在标志物，特别是在阴性蛋白尿的sled相关肾损伤中。甘油三酯联合蛋白尿可有效预测sle相关性肾损伤。
Fewer biomarkers can be used to predict systemic lupus erythematosus (SLE) related kidney injury. This paper presents an apriori algorithm of association rules to mine the predictive biomarkers for SLE-related kidney injury of negative proteinuria. An apriori algorithm of association rules was employed to identify biomarkers, and logistic regression analysis and spearman correlation analysis were used to evaluate the correlation between triglycerides and SLE-related kidney injury of negative proteinuria. Triglycerides were mined out by the apriori algorithm of association rules. The level of triglycerides was significantly higher, and it was an independent risk factor for SLE-related kidney injury. In the high-triglycerides group, the number of patients with SLE-related kidney injury, SLEDAI-2K, urine P-CAST, the level of blood urea nitrogen, serum creatinine, and proteinuria were increased. Triglycerides level was positively correlated with proteinuria and P-CAST and negatively correlated with albumin and IgG. The area under the ROC curve of triglycerides and triglycerides combined proteinuria was 0.72 and 0.82, respectively. Significantly, 50% of SLE-related kidney injuries of negative proteinuria could be identified by high triglycerides levels. High triglycerides level was found at the time of onset of kidney injury, and it was opposite to glomerular filtration rate. Triglycerides may be a potential marker for predicting SLE-related kidney injury, especially in SLE-related kidney injury of negative proteinuria. Triglycerides combined proteinuria could predict SLE-related kidney injury effectively.
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影响因子：
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