Post-translational modifications in MeHg-induced neurotoxicity.
Post-translational modifications in MeHg-induced neurotoxicity.
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MEHG诱导的神经毒性的翻译后修饰。
DOI：
10.1016/j.bbadis.2018.10.024
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发表时间：
2019-08-01
期刊：
影响因子：
--
通讯作者：
Aschner M
中科院分区：
文献类型：
--
作者：
Ke T;Gonçalves FM;Gonçalves CL;Dos Santos AA;Rocha JBT;Farina M;Skalny A;Tsatsakis A;Bowman AB;Aschner M
Mercury (Hg) exposure remains a major public health concern due to its widespread distribution in the environment. Organic mercurials, such as MeHg, have been extensively investigated especially because of their congenital effects. In this context, studies on the molecular mechanism of MeHg-induced neurotoxicity are pivotal to the understanding of its toxic effects and the development of preventive measures. Post-translational modifications (PTMs) of proteins, such as phosphorylation, ubiquitination, and acetylation are essential for the proper function of proteins and play important roles in the regulation of cellular homeostasis. The rapid and transient nature of many PTMs allows efficient signal transduction in response to stress. This review summarizes the current knowledge of PTMs in MeHg-induced neurotoxicity, including the most commonly PTMs, as well as PTMs induced by oxidative stress and PTMs of antioxidant proteins. Though PTMs represent an important molecular mechanism for maintaining cellular homeostasis and are involved in the neurotoxic effects of MeHg, we are far from understanding the complete picture on their role, and further research is warranted to increase our knowledge of PTMs in MeHg-induced neurotoxicity.
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DOI：
10.1042/bcj20160082
发表时间：
2016-08-15
期刊：
The Biochemical journal
影响因子：
--
作者：
Bishop P;Rocca D;Henley JM
通讯作者：
Henley JM
影响因子：
2.9
作者：
ASCHNER, M;DU, YL;KIMELBERG, HK
通讯作者：
KIMELBERG, HK
影响因子：
3.7
作者：
Carvan MJ 3rd;Kalluvila TA;Klingler RH;Larson JK;Pickens M;Mora-Zamorano FX;Connaughton VP;Sadler-Riggleman I;Beck D;Skinner MK
通讯作者：
Skinner MK
影响因子：
3.8
作者：
Bose, Raj;Onishchenko, Natalia;Ceccatelli, Sandra
通讯作者：
Ceccatelli, Sandra
影响因子：
2.9
作者：
ASCHNER, M;CLARKSON, TW
通讯作者：
CLARKSON, TW