Epithelial-mesenchymal interactions in biliary diseases.
Epithelial-mesenchymal interactions in biliary diseases.
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DOI：
10.1055/s-0031-1272832
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发表时间：
2011-02
影响因子：
4.2
通讯作者：
Strazzabosco M
中科院分区：
文献类型：
--
作者：
Fabris L;Strazzabosco M
在大多数胆管病、不同病因的肝脏疾病中，胆管上皮是致病序列的主要靶标，其核心机制涉及炎症。炎症的特征是含有成纤维细胞、巨噬细胞、淋巴细胞以及内皮细胞和周细胞的多形性胆周浸润，与“反应性胆管细胞”的出现有关。这些胆管细胞不具有胆汁分泌功能，与末端胆管相邻，并且具有分化程度较低的表型。它们获得了多种间充质特性，包括分泌大量促炎化学物质/细胞因子和生长因子的运动性和能力，以及丰富的受体机制的从头表达。这些功能特性使反应性胆管细胞能够建立密切接触，并与门浸润中不同类型的间充质细胞相互交换各种旁分泌信号。上皮细胞和间质细胞之间的广泛串扰是胆管病中肝脏修复机制的驱动因素，最终演变成门静脉纤维化。在此，作者首先回顾了参与相互作用的不同细胞类型的特性，然后分析了它们与胆管病肝脏修复相关的潜在分子机制。
In most cholangiopathies, liver diseases of different etiologies in which the biliary epithelium is the primary target in the pathogenic sequence, the central mechanism involves inflammation. Inflammation, characterized by pleomorphic peribiliary infiltrate containing fibroblasts, macrophages, lymphocytes, as well as endothelial cells and pericytes, is associated to the emergence of “reactive cholangiocytes.” These biliary cells do not possess bile secretory functions, are in contiguity with terminal cholangioles, and are of a less-differentiated phenotype. They have acquired several mesenchymal properties, including motility and ability to secrete a vast number of proinflammatory chemo/cytokines and growth factors along with de novo expression of a rich receptor machinery. These functional properties enable reactive cholangiocytes to establish intimate contacts and to mutually exchange a variety of paracrine signals with the different mesenchymal cell types populating the portal infiltrate. The extensive crosstalk between the epithelial and mesenchymal compartments is the driver of liver repair mechanisms in cholangiopathies, ultimately evolving toward portal fibrosis. Herein, the authors first review the properties of the different cell types involved in their interaction, and then analyze the underlying molecular mechanisms as they relate to liver repair in cholangiopathies.
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影响因子：
13.5
作者：
Ankoma-Sey, V;Wang, Y;Dai, ZH
通讯作者：
Dai, ZH
DOI：
10.1073/pnas.96.15.8585
发表时间：
1999-07-20
影响因子：
11.1
作者：
Coulomb-L'Herminé, A;Amara, A;Emilie, D
通讯作者：
Emilie, D
影响因子：
13.5
作者：
Crosnier, C;Attié-Bitach, T;Vekemans, M
通讯作者：
Vekemans, M
DOI：
10.1111/j.1440-1746.2006.04708.x
发表时间：
2007-11-01
影响因子：
4.1
作者：
Asawa, Sadanori;Saito, Takuro;Gotoh, Mitsukazu
通讯作者：
Gotoh, Mitsukazu
胆管癌：发病机理，诊断和治疗的进展。
影响因子：
13.5
作者：
Blechacz, Boris;Gores, Gregory J.
通讯作者：
Gores, Gregory J.