The Effect of Multifocal Soft Contact Lens Wear on Axial and Peripheral Eye Elongation in the BLINK Study.
The Effect of Multifocal Soft Contact Lens Wear on Axial and Peripheral Eye Elongation in the BLINK Study.
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DOI：
10.1167/iovs.63.10.17
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发表时间：
2022-09-01
影响因子：
4.4
通讯作者：
中科院分区：
文献类型：
--
作者：
本研究的目的是比较多焦点软隐形眼镜近视治疗期间眼轴和周边眼的伸长率。参与者为 294 名儿童（177 [60.2%] 女孩），年龄 7 至 11 岁，近视度数 (D) 至 -5.00 D 之间（球面分量），基线散光度小于 1.00 D。儿童被随机分配佩戴 Biofinity 软隐形眼镜 3 年：D 型设计，+2.50 D 附加值、+1.50 D 附加值或单光。使用 Haag-Streit Lenstar LS 900 对右眼的中央凹、±20° 和 ±30° 的右眼水平和垂直子午线进行五次眼长测量的平均值。使用单光隐形眼镜 3 年期间的眼轴伸长率比上侧和颞部视网膜的周边伸长率大 0.07 毫米（95% 置信区间 [CI] = 0.05 至 0.09） mm）和 0.06 mm（95% CI = 0.03 至 0.09 mm），下象限和鼻象限相似。 +2.50D附加多焦点隐形眼镜的轴向伸长率与视网膜上象限的周边伸长率相似，并且比下象限和鼻象限的周边伸长率小-0.04毫米（95％CI = -0.06至-0.01毫米）和-0.06毫米（95％CI = -0.09至-0.02毫米）。佩戴+2.50 D 多焦点隐形眼镜可以中和或逆转单光镜片引起的视网膜陡度增加。尽管周边近视散焦更大，但中央凹处对伸长的更大抑制之间的不匹配表明，光学近视治疗可能通过广泛的空间整合或局部散焦以外的机制来进行。
The purpose of this study was to compare axial and peripheral eye elongation during myopia therapy with multifocal soft contact lenses. Participants were 294 children (177 [60.2%] girls) age 7 to 11 years old with between −0.75 diopters (D) and −5.00 D of myopia (spherical component) and less than 1.00 D astigmatism at baseline. Children were randomly assigned to Biofinity soft contact lenses for 3 years: D-designs with a +2.50 D addition, +1.50 D addition, or single vision. Five measurements of eye length were averaged at the fovea, ±20°, and ±30° in the horizontal and vertical meridians of the right eye using the Haag-Streit Lenstar LS 900. Axial elongation over 3 years with single vision contact lenses was greater than peripheral elongation in the superior and temporal retinal qeuadrants by 0.07 mm (95% confidence interval [CI] = 0.05 to 0.09 mm) and 0.06 mm (95% CI = 0.03 to 0.09 mm) and similar in the inferior and nasal quadrants. Axial elongation with +2.50 D addition multifocal contact lenses was similar to peripheral elongation in the superior retinal quadrant and less than peripheral elongation in the inferior and nasal quadrants by −0.04 mm (95% CI = −0.06 to −0.01 mm) and −0.06 mm (95% CI = −0.09 to −0.02 mm). Wearing +2.50 D addition multifocal contact lenses neutralized or reversed the increase in retinal steepness with single vision lenses. The mismatch between greater inhibition of elongation at the fovea than peripherally despite greater peripheral myopic defocus suggests that optical myopia therapy may operate through extensive spatial integration or mechanisms other than local defocus.
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影响因子：
4.4
作者：
Berntsen, David A.;Sinnott, Loraine T.;Zadnik, Karla
通讯作者：
Zadnik, Karla
影响因子：
4.4
作者：
Gwiazda, J;Hyman, L;Scheiman, M
通讯作者：
Scheiman, M
影响因子：
1.4
作者：
Queiros, Antonio;Manuel Gonzalez-Meijome, Jose;Gutierrez, Angel R.
通讯作者：
Gutierrez, Angel R.
影响因子：
1.8
作者：
Schippert, Ruth;Schaeffel, Frank
通讯作者：
Schaeffel, Frank
影响因子：
4.2
作者：
MILLERMEEKS, MJ;BENNETT, SR;BLODI, CF
通讯作者：
BLODI, CF