RNAssess--a web server for quality assessment of RNA 3D structures.
RNAssess--a web server for quality assessment of RNA 3D structures.
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DOI:
10.1093/nar/gkv557
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发表时间:
2015-07-01
影响因子:
14.9
通讯作者:
Blazewicz J
中科院分区:
文献类型:
--
作者:
Lukasiak P;Antczak M;Ratajczak T;Szachniuk M;Popenda M;Adamiak RW;Blazewicz J
Nowadays, various methodologies can be applied to model RNA 3D structure. Thus, the plausible quality assessment of 3D models has a fundamental impact on the progress of structural bioinformatics. Here, we present RNAssess server, a novel tool dedicated to visual evaluation of RNA 3D models in the context of the known reference structure for a wide range of accuracy levels (from atomic to the whole molecule perspective). The proposed server is based on the concept of local neighborhood, defined as a set of atoms observed within a sphere localized around a central atom of a particular residue. A distinctive feature of our server is the ability to perform simultaneous visual analysis of the model-reference structure coherence. RNAssess supports the quality assessment through delivering both static and interactive visualizations that allows an easy identification of native-like models and/or chosen structural regions of the analyzed molecule. A combination of results provided by RNAssess allows us to rank analyzed models. RNAssess offers new route to a fast and efficient 3D model evaluation suitable for the RNA-Puzzles challenge. The proposed automated tool is implemented as a free and open to all users web server with an user-friendly interface and can be accessed at: http://rnassess.cs.put.poznan.pl/
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