T cell subsets and functions in atherosclerosis.
T cell subsets and functions in atherosclerosis.
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DOI：
10.1038/s41569-020-0352-5
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发表时间：
2020-07
期刊：
影响因子：
--
通讯作者：
Ley K
中科院分区：
文献类型：
--
作者：
Saigusa R;Winkels H;Ley K
动脉粥样硬化是动脉壁的慢性炎症性疾病，是心血管疾病的主要潜在原因。包括小鼠体内成像、细胞谱系追踪和基因敲除研究以及临床干预研究和先进的mRNA测序技术在内的方法引起了人们对T细胞作为动脉粥样硬化发病机制的关键驱动因素和修饰剂的作用的关注。CD 4 + T细胞通常存在于动脉粥样硬化斑块中。大量证据表明，辅助性T细胞1（TH 1）具有促动脉粥样硬化作用，调节性T细胞（Treg）具有抗动脉粥样硬化作用。然而，Treg细胞可以成为促动脉粥样硬化的。其他TH细胞亚群如TH 2、TH 9、TH 17、TH 22、滤泡辅助T细胞和CD 28- T细胞以及其他T细胞亚群包括CD 8 + T细胞和γδT细胞在动脉粥样硬化中的作用还不太清楚。此外，一些T细胞似乎具有促动脉粥样硬化和抗动脉粥样硬化的功能。本文就T细胞亚群及其在动脉粥样硬化中的作用和T细胞归巢动脉粥样硬化斑块的过程作一综述。我们对T细胞在动脉粥样硬化中的作用的大部分理解是基于实验模型的发现。将这些发现转化为人类疾病具有挑战性，但非常需要。靶向T细胞及其特异性细胞因子是开发新的预防和治疗方法的有吸引力的途径，包括动脉粥样硬化的潜在T细胞相关疗法。
Atherosclerosis is a chronic inflammatory disease of the arterial wall and the primary underlying cause of cardiovascular diseases. Approaches including in vivo imaging, cell-lineage tracing and knockout studies in mice, as well as clinical interventional studies and advanced mRNA sequencing techniques have drawn attention to the role of T cells as critical drivers and modifiers of the pathogenesis of atherosclerosis. CD4+ T cells are commonly found in atherosclerotic plaques. A large body of evidence indicates that T helper 1 (TH1) cells have pro-atherogenic roles and regulatory T (Treg) cells anti-atherogenic roles. However, Treg cells can become pro-atherogenic. The roles in atherosclerosis of other TH cell subsets such as TH2, TH9, TH17, TH22, follicular helper T cells and CD28– T cells, as well as other T cell subsets including CD8+ T cells and γδT cells, are less well understood. Moreover, some T cells seem to have both pro-atherogenic and anti-atherogenic functions. In this Review, we summarize the knowledge on T cell subsets, their functions in atherosclerosis and the process of T cell homing to atherosclerotic plaques. Much of our understanding of T cell roles in atherosclerosis is based on findings from experimental models. Translating these findings into human disease is challenging, but much needed. Targeting T cells and their specific cytokines are attractive pathways for developing new preventative and therapeutic approaches including potential T cell-related therapies for atherosclerosis.
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影响因子：
82.9
作者：
Ait-Oufella, H;Salomon, BL;Mallat, Z
通讯作者：
Mallat, Z
影响因子：
32.4
作者：
Bailey-Bucktrout, Samantha L.;Martinez-Llordella, Marc;Zhou, Xuyu;Anthony, Bryan;Rosenthal, Wendy;Luche, Herve;Fehling, Hans J.;Bluestone, Jeffrey A.
通讯作者：
Bluestone, Jeffrey A.
DOI：
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发表时间：
2011-05-06
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
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通讯作者：
Nolan GP
影响因子：
10.8
作者：
Brauner, Susanna;Jiang, Xintong;Wahren-Herlenius, Marie
通讯作者：
Wahren-Herlenius, Marie
DOI：
10.1161/01.atv.11.5.1223
发表时间：
1991-09-01
期刊：
ARTERIOSCLEROSIS AND THROMBOSIS
影响因子：
--
作者：
AMENTO, EP;EHSANI, N;LIBBY, P
通讯作者：
LIBBY, P