β-N-methylamino-L-alanine induces neurological deficits and shortened life span in Drosophila.
β-N-methylamino-L-alanine induces neurological deficits and shortened life span in Drosophila.
复制标题
作者：
Zhou X;Escala W;Papapetropoulos S;Zhai RG
The neurotoxic non-protein amino acid, β-N-methylamino-L-alanine (BMAA), was first associated with the high incidence of Amyotrophic Lateral Sclerosis/Parkinsonism Dementia Complex (ALS/PDC) in Guam. Recently, BMAA has been implicated as a fierce environmental factor that contributes to the etiology of Alzheimer’s and Parkinson’s diseases, in addition to ALS. However, the toxicity of BMAA in vivo has not been clearly demonstrated. Here we report our investigation of the neurotoxicity of BMAA in Drosophila. We found that dietary intake of BMAA reduced life span, locomotor functions, and learning and memory abilities in flies. The severity of the alterations in phenotype is correlated with the concentration of BMAA detected in flies. Interestingly, developmental exposure to BMAA had limited impact on survival rate, but reduced fertility in females, and caused delayed neurological impairment in aged adults. Our studies indicate that BMAA exposure causes chronic neurotoxicity, and that Drosophila serves as a useful model in dissecting the pathogenesis of ALS/PDC.
登录
查看更多内容
DOI：
10.1007/s00359-004-0574-8
发表时间：
2005-03-01
影响因子：
2.1
作者：
Hendel, T;Michels, B;Gerber, B
通讯作者：
Gerber, B
影响因子：
9.9
作者：
Cox, PA;Sacks, OW
通讯作者：
Sacks, OW
DOI：
10.1073/pnas.2235808100
发表时间：
2003-11-11
影响因子：
11.1
作者：
Cox, PA;Banack, SA;Murch, SJ
通讯作者：
Murch, SJ
影响因子：
--
作者：
Lobner, Doug
通讯作者：
Lobner, Doug
影响因子：
5.3
作者：
Liu, XiaoQian;Rush, Travis;Lobner, Doug
通讯作者：
Lobner, Doug