Computational and bioinformatics frameworks for next-generation whole exome and genome sequencing.
Computational and bioinformatics frameworks for next-generation whole exome and genome sequencing.
复制标题
DOI：
10.1155/2013/730210
复制
发表时间：
2013
影响因子：
--
通讯作者：
Lin JC
中科院分区：
文献类型：
--
作者：
Dolled-Filhart MP;Lee M Jr;Ou-Yang CW;Haraksingh RR;Lin JC
It has become increasingly apparent that one of the major hurdles in the genomic age will be the bioinformatics challenges of next-generation sequencing. We provide an overview of a general framework of bioinformatics analysis. For each of the three stages of (1) alignment, (2) variant calling, and (3) filtering and annotation, we describe the analysis required and survey the different software packages that are used. Furthermore, we discuss possible future developments as data sources grow and highlight opportunities for new bioinformatics tools to be developed.
登录
查看更多内容
影响因子：
48
作者：
Langmead, Ben;Salzberg, Steven L.
通讯作者：
Salzberg, Steven L.
影响因子：
14.8
作者：
Kumar, Prateek;Henikoff, Steven;Ng, Pauline C.
通讯作者：
Ng, Pauline C.
影响因子：
30.8
作者：
Alkan, Can;Kidd, Jeffrey M.;Marques-Bonet, Tomas;Aksay, Gozde;Antonacci, Francesca;Hormozdiari, Fereydoun;Kitzman, Jacob O.;Baker, Carl;Malig, Maika;Mutlu, Onur;Sahinalp, S. Cenk;Gibbs, Richard A.;Eichler, Evan E.
通讯作者：
Eichler, Evan E.
影响因子：
1.2
作者：
Cingolani, Pablo;Platts, Adrian;Ruden, Douglas M.
通讯作者：
Ruden, Douglas M.
影响因子：
14.9
作者：
De Baets G;Van Durme J;Reumers J;Maurer-Stroh S;Vanhee P;Dopazo J;Schymkowitz J;Rousseau F
通讯作者：
Rousseau F