The relevance of uniform reporting in oral leukoplakia: definition, certainty factor and staging based on experience with 275 patients.
The relevance of uniform reporting in oral leukoplakia: definition, certainty factor and staging based on experience with 275 patients.
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DOI：
10.4317/medoral.18756
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发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
van der Waal I
中科院分区：
文献类型：
--
作者：
Brouns ER;Baart JA;Bloemena E;Karagozoglu H;van der Waal I
本研究的目的是评估世界卫生组织于 2005 年提出的口腔白斑的定义，并考虑到先前报告的分类和分期系统，包括使用四个级别的确定性因子来确定白斑的诊断。 1997 年至 2012 年期间，对医院内连续 275 名临时诊断为口腔白斑的患者进行了检查。根据严格的临床病理学标准，在这 275 名患者中，只有 176 名患者被明确诊断为白斑。随后使用基于体型和组织病理学特征的分类和分期系统对 176 名患者进行了分期。对于流行病学研究来说，基于单次口腔检查的白斑诊断似乎是可以接受的（确定性级别 1）。对于管理和恶性转化率的研究，建议包括切开或切除活检的组织病理学检查的要求，分别代表确定性级别 3 和 4。该建议得出了口腔白斑的以下定义：“主要是白色病变或行为可疑的斑块，在临床和组织病理学上排除了任何其他可定义的白色疾病或紊乱”。此外，我们建议对已确定致病因素的主要白色病变使用严格的诊断标准，例如吸烟者病变、摩擦病变和牙齿修复相关病变。 关键词：口腔上皮发育不良、口腔白斑、潜在恶性口腔疾病。
The aim of the present study was to evaluate the definition of oral leukoplakia, proposed by the WHO in 2005 and taking into account a previously reported classification and staging system, including the use of a Certainty factor of four levels with which the diagnosis of leukoplakia can be established. In the period 1997-2012 a hospital-based population of 275 consecutive patients with a provisional diagnosis of oral leukoplakia has been examined. In only 176 patients of these 275 patients a firm diagnosis of leukoplakia has been established based on strict clinicopathological criteria. The 176 patients have subsequently been staged using a classification and staging system based on size and histopathologic features. For use in epidemiological studies it seems acceptable to accept a diagnosis of leukoplakia based on a single oral examination (Certainty level 1). For studies on management and malignant transformation rate the recommendation is made to include the requirement of histopathologic examination of an incisional or excisional biopsy, representing Certainty level 3 and 4, respectively. This recommendation results in the following definition of oral leukoplakia: “A predominantly white lesion or plaque of questionable behaviour having excluded, clinically and histopathologically, any other definable white disease or disorder”. Furthermore, we recommend the use of strict diagnostic criteria for predominantly white lesions for which a causative factor has been identified, e.g. smokers’ lesion, frictional lesion and dental restoration associated lesion. Key words:Oral epithelial dysplasia, oral leukoplakia, potentially malignant oral disorders.
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影响因子：
3.3
作者：
van der Meij, EH;van der Waal, I
通讯作者：
van der Waal, I
DOI：
10.14219/jada.archive.2007.0236
发表时间：
2007-05-01
影响因子：
3.9
作者：
Chi, Angela C.;Lambert, Paul R., III;Neville, Brad W.
通讯作者：
Neville, Brad W.
影响因子：
1.9
作者：
Mignogna, Michele D.;Fortuna, Giulio;Cafiero, Carlo
通讯作者：
Cafiero, Carlo
影响因子：
13.8
作者：
Natarajan, Easwar;Woo, Sook-Bin
通讯作者：
Woo, Sook-Bin
影响因子：
4.8
作者：
Kujan, Omar;Oliver, Richard J.;Sloan, Philip
通讯作者：
Sloan, Philip