The role of surface functionality in determining nanoparticle cytotoxicity.
The role of surface functionality in determining nanoparticle cytotoxicity.
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DOI：
10.1021/ar3000647
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发表时间：
2013-03-19
影响因子：
18.3
通讯作者：
Rotello, Vincent M.
中科院分区：
文献类型：
--
作者：
Kim, Sung Tae;Saha, Krishnendu;Kim, Chaekyu;Rotello, Vincent M.
表面性质决定了纳米材料在体外、体内和环境中的行为。这些性质包括表面电荷和疏水性。同样关键的是更复杂的超分子相互作用，如芳香堆积和氢键，甚至从结构到原子水平的表面拓扑结构。纳米粒子的表面功能化提供了一种有效的方法来控制纳米材料和它们被设计为与之相互作用的生物系统之间的界面。例如，在医学中，适当控制表面特性可以最大限度地提高治疗或成像效果，同时最大限度地减少不利的副作用。同时，在环境科学中，精心选择颗粒涂层可以最大限度地减少人造纳米材料对环境的影响。全面了解具有各种特性的NP表面如何影响生物系统对于创建具有低毒性，稳定性，生物相容性，在细胞或组织中良好分布以及良好的药代动力学特性等有用的治疗和成像特性的NP以及减少人造纳米材料的潜在环境影响至关重要，这些材料在市场上变得越来越突出。在这个帐户中，我们讨论了我们的研究和其他人如何NP表面特性控制与生物分子和细胞在许多尺度上的相互作用，包括颗粒表面在确定纳米材料的体内行为中所起的作用。这些相互作用可能是良性的、有益的，或导致蛋白质、基因和细胞功能障碍，从而导致细胞毒性和遗传毒性反应。了解这些相互作用及其后果有助于我们设计微创成像和输送剂。我们还强调在这个帐户中，我们如何制造纳米粒子作为治疗剂通过定制的相互作用与生物大分子。这些颗粒提供了传统小分子疗法的新治疗方向，并且具有比蛋白质和核酸更大的潜在通用性。
Surface properties dictate the behavior of nanomaterials in vitro, in vivo and in the environment. Such properties include surface charge and hydrophobicity. Also key are more complex supramolecular interactions like aromatic stacking and hydrogen bonding, and even surface topology from the structural to the atomic level. Surface functionalization of nanoparticles (NPs) provides an effective way to control the interface between nanomaterials and the biological systems they are designed to interact with. In medicine, for instance, proper control of surface properties can maximize therapeutic or imaging efficacy while minimizing unfavorable side effects. Meanwhile, in environmental science, thoughtful choice of particle coating can minimize the impact of manufactured nanomaterials on the environment. A thorough knowledge of how NP surfaces with various properties effect biological systems is essential for creating NPs with such useful therapeutic and imaging properties as low toxicity, stability, biocompatibility, favorable distribution throughout cells or tissues, and favorable pharmacokinetic profiles--and for reducing the potential environmental impact of manufactured nanomaterials, which are becoming increasingly prominent in the marketplace. In this Account, we discuss our research and that of others into how NP surface properties control interactions with biomolecules and cells at many scales, including the role the particle surface plays in determining in vivo behavior of nanomaterials. These interactions can be benign, beneficial, or lead to dysfunction in proteins, genes and cells, resulting in cytotoxic and genotoxic responses. Understanding these interactions and their consequences helps us to design minimally invasive imaging and delivery agents. We also highlight in this Account how we have fabricated nanoparticles to act as therapeutic agents via tailored interactions with biomacromolecules. These particles offer new therapeutic directions from traditional small molecule therapies, and with potentially greater versatility than is possible with proteins and nucleic acids.
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影响因子：
15
作者：
Agasti SS;Chompoosor A;You CC;Ghosh P;Kim CK;Rotello VM
通讯作者：
Rotello VM
影响因子：
21.8
作者：
通讯作者：
--
影响因子：
12.8
作者：
Chang, Christopher
通讯作者：
Chang, Christopher
影响因子：
15
作者：
Fischer, NO;Verma, A;Rotello, VM
通讯作者：
Rotello, VM
影响因子：
16.1
作者：
Aggarwal P;Hall JB;McLeland CB;Dobrovolskaia MA;McNeil SE
通讯作者：
McNeil SE