RNA polymerase II C-terminal domain: Tethering transcription to transcript and template.
RNA polymerase II C-terminal domain: Tethering transcription to transcript and template.
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DOI：
10.1021/cr400158h
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发表时间：
2013-11-13
期刊：
影响因子：
62.1
通讯作者：
Corden, Jeffry L.
中科院分区：
文献类型：
--
作者：
Corden, Jeffry L.
By definition the CTD consists of the amino acid sequences extending from the largest subunit, RPO21 or RPB1 in yeast and POLR2A in human. Specifically the CTD consists of sequences beyond the most C-terminal region that is conserved among the largest subunits of all multisubunit RNA polymerases. 1 This “H” homology region plays a role in positioning the catalytic core and provides surfaces for interactions with Rpb2 and Rpb6. 2 The CTD thus consists of three regions (Figure 1). In order of proximity to the catalytic core these are the linker, the heptad repeats, and a C-terminal nonrepeat or “tip” domain. The linker region is not conserved among different organisms but does contain an enrichment of amino acids found in the CTD. The heptad repeat domain consists of multiple tandem repeats of the consensus sequence YSPTSPS. Since this sequences is tandemly repeated the consensus could be any one of seven permutations of this sequence. The selection of Tyr as position one is essentially arbitrary and other permutations have been proposed. 1 Because the Tyr in position one is more universally adopted in the literature we will use this nomenclature in this review.The discovery of the CTD in the mid-1980s 3 explained the multiple forms of Pol II that were identified by ion exchange chromatography. 4, 5 These forms, termed Pol IIO, IIA, and IIB differed by the mobility in SDS gels of the largest subunit termed IIo, IIa, and IIb, respectively (Figure 2). Comparing the amino
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影响因子：
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作者：
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影响因子：
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作者：
Bartkowiak, Bartlomiej;Liu, Pengda;Greenleaf, Arno L.
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Greenleaf, Arno L.
影响因子：
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影响因子：
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DOI：
10.1073/pnas.86.8.2794
发表时间：
1989-04-01
影响因子：
11.1
作者：
ALLISON, LA;INGLES, CJ
通讯作者：
INGLES, CJ