Cell-to-cell spread of HIV-1 and evasion of neutralizing antibodies.
Cell-to-cell spread of HIV-1 and evasion of neutralizing antibodies.
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HIV-1 的细胞间传播和中和抗体的逃避。
DOI：
10.1016/j.vaccine.2013.10.020
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发表时间：
2013
期刊：
影响因子：
5.5
通讯作者：
C. Duncan
中科院分区：
文献类型：
--
作者：
Torben Schiffner;Q. Sattentau;C. Duncan
20 多年前首次观察到人类免疫缺陷病毒 (HIV-1) 在免疫细胞之间进行细胞间传播。在此期间，这种感染途径是否有利于病毒逃避针对病毒包膜糖蛋白（Env）的中和抗体（NAb）的问题已被反复研究，但结果相互矛盾。过去几年，随着更广泛的中和抗体被分离出来，我们对 HIV-1 在病毒学和感染性突触传播的机制有了更深入的了解，一幅更清晰的图景已经形成。然而，仍然缺乏共识，这种情况至少可以部分解释为用于研究细胞间中NAb活性的实验方法的可变性。在这篇综述中，我们重点关注有关 NAb 对抗细胞间传播活性的最关键问题：NAb 对细胞间 HIV-1 的抑制在数量上或质量上与无细胞感染不同吗？总体而言，数据一致表明，NAb 能够阻断突触处的 HIV-1 感染，这支持了细胞间感染通过病毒颗粒直接转移至外部环境而发生的概念。然而，最近的研究结果表明，可能需要更高浓度的某些 NAb 来抑制突触感染，这对预防性疫苗的开发具有重要的潜在影响。我们讨论了这种相对和选择性活性丧失的几种机制解释，并强调了仍有待探索的知识差距。
Cell-to-cell spread of human immunodeficiency virus (HIV-1) between immune cells was first observed over 20 years ago. During this time, the question of whether this infection route favours viral evasion of neutralizing antibodies (NAbs) targeting the virus envelope glycoprotein (Env) has been repeatedly investigated, but with conflicting results. A clearer picture has formed in the last few years as more broadly neutralizing antibodies have been isolated and we gain further insight into the mechanisms of HIV-1 transmission at virological and infectious synapses. Nevertheless consensus is still lacking, a situation which may be at least partly explained by variability in the experimental approaches used to study the activity of NAbs in the cell-to-cell context. In this review we focus on the most critical question concerning the activity of NAbs against cell-to-cell transmission: is NAb inhibition of cell-to-cell HIV-1 quantitatively or qualitatively different from cell-free infection? Overall, data consistently show that NAbs are capable of blocking HIV-1 infection at synapses, supporting the concept that cell-to-cell infection occurs through directed transfer of virions accessible to the external environment. However, more recent findings suggest that higher concentrations of certain NAbs might be needed to inhibit synaptic infection, with important potential implications for prophylactic vaccine development. We discuss several mechanistic explanations for this relative and selective loss of activity, and highlight gaps in knowledge that are still to be explored.
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DOI：
10.1084/jem.20120423
发表时间：
2012-07-30
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Klein F;Gaebler C;Mouquet H;Sather DN;Lehmann C;Scheid JF;Kraft Z;Liu Y;Pietzsch J;Hurley A;Poignard P;Feizi T;Morris L;Walker BD;Fätkenheuer G;Seaman MS;Stamatatos L;Nussenzweig MC
通讯作者：
Nussenzweig MC
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
32.4
作者：
Sun, Zhen-Yu J.;Oh, Kyoung Joon;Reinherz, Ellis L.
通讯作者：
Reinherz, Ellis L.
影响因子：
56.9
作者：
BURTON, DR;PYATI, J;BARBAS, CF
通讯作者：
BARBAS, CF
HIV-1 疫苗功效试验的免疫相关分析。
DOI：
10.1056/nejmoa1113425
发表时间：
2012-04-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Haynes BF;Gilbert PB;McElrath MJ;Zolla-Pazner S;Tomaras GD;Alam SM;Evans DT;Montefiori DC;Karnasuta C;Sutthent R;Liao HX;DeVico AL;Lewis GK;Williams C;Pinter A;Fong Y;Janes H;DeCamp A;Huang Y;Rao M;Billings E;Karasavvas N;Robb ML;Ngauy V;de Souza MS;Paris R;Ferrari G;Bailer RT;Soderberg KA;Andrews C;Berman PW;Frahm N;De Rosa SC;Alpert MD;Yates NL;Shen X;Koup RA;Pitisuttithum P;Kaewkungwal J;Nitayaphan S;Rerks-Ngarm S;Michael NL;Kim JH
通讯作者：
Kim JH