FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes.
FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes.
复制标题
FAM210A对棕色脂肪细胞中冷诱导的线粒体重塑至关重要。
DOI：
10.1038/s41467-023-41988-y
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发表时间：
2023-10-10
影响因子：
16.6
通讯作者：
Kuang, Shihuan
中科院分区：
文献类型：
--
作者：
Qiu, Jiamin;Yue, Feng;Zhu, Peipei;Chen, Jingjuan;Xu, Fan;Zhang, Lijia;Kim, Kun Ho;Snyder, Madigan M.;Luo, Nanjian;Xu, Hao-wei;Huang, Fang;Tao, W. Andy;Kuang, Shihuan
Cold stimulation dynamically remodels mitochondria in brown adipose tissue (BAT) to facilitate non-shivering thermogenesis in mammals, but what regulates mitochondrial plasticity is poorly understood. Comparing mitochondrial proteomes in response to cold revealed FAM210A as a cold-inducible mitochondrial inner membrane protein. An adipocyte-specific constitutive knockout of Fam210a (Fam210aAKO) disrupts mitochondrial cristae structure and diminishes the thermogenic activity of BAT, rendering the Fam210aAKO mice vulnerable to lethal hypothermia under acute cold exposure. Induced knockout of Fam210a in adult adipocytes (Fam210aiAKO) does not affect steady-state mitochondrial structure under thermoneutrality, but impairs cold-induced mitochondrial remodeling, leading to progressive loss of cristae and reduction of mitochondrial density. Proteomics reveals an association between FAM210A and OPA1, whose cleavage governs cristae dynamics and mitochondrial remodeling. Mechanistically, FAM210A interacts with mitochondrial protease YME1L and modulates its activity toward OMA1 and OPA1 cleavage. These data establish FAM210A as a key regulator of mitochondrial cristae remodeling in BAT and shed light on the mechanism underlying mitochondrial plasticity in response to cold. Mammalians rely on brown adipocytes to generate heat under cold exposure, this thermogenic function requires dynamic remodeling of the mitochondria. Here the authors identify a protein called FAM210A as a key regulator of cold-induced mitochondrial remodeling in brown adipocytes.
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影响因子：
64.5
作者：
Fedorenko A;Lishko PV;Kirichok Y
通讯作者：
Kirichok Y
影响因子：
14.8
作者：
Frezza, Christian;Cipolat, Sara;Scorrano, Luca
通讯作者：
Scorrano, Luca
影响因子：
64.8
作者：
Chouchani ET;Kazak L;Jedrychowski MP;Lu GZ;Erickson BK;Szpyt J;Pierce KA;Laznik-Bogoslavski D;Vetrivelan R;Clish CB;Robinson AJ;Gygi SP;Spiegelman BM
通讯作者：
Spiegelman BM
影响因子：
29
作者：
Ahola, Sofia;Mejias, Pablo Rivera;Langer, Thomas
通讯作者：
Langer, Thomas
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影响因子：
9
作者：
Hu C;Shu L;Huang X;Yu J;Li L;Gong L;Yang M;Wu Z;Gao Z;Zhao Y;Chen L;Song Z
通讯作者：
Song Z