Screening for excessive alcohol drinking. Comparative value of carbohydrate-deficient transferrin, gamma-glutamyltransferase, and mean corpuscular volume.
Screening for excessive alcohol drinking. Comparative value of carbohydrate-deficient transferrin, gamma-glutamyltransferase, and mean corpuscular volume.
复制标题
筛查过量饮酒。
DOI：
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复制
发表时间：
1995
影响因子：
--
通讯作者：
Alain Pécoud
中科院分区：
文献类型：
--
作者：
B. Yersin;Jean;Hedy Decrey;Michel Burnier;G. V. Melle;Alain Pécoud
背景
筛查医疗患者是否过度饮酒非常重要，因为医生的最小干预就可以有效减少过度饮酒。因此，应研究筛查测试，例如饮酒的生物标记物，以评估其检测饮酒的有效性。
方法
对在城市和教学医院的医疗急诊病房 (n = 552) 和初级保健中心 (n = 650) 就诊的 1202 名连续患者（20 至 75 岁）测定了碳水化合物缺乏的转铁蛋白 (CDT)、γ-谷氨酰转移酶 (GGT) 和平均红细胞体积 (MCV) 水平。每位符合条件的患者都接受了一份 CAGE 问卷（关于减少饮酒、对他人对饮酒的担忧感到恼火、对饮酒感到内疚以及在早上使用酒精作为开眼界等问题的缩写），并且对于每位 CAGE 阳性患者（分数 > 或 = 2）以及随机性别匹配的 CAGE 阴性患者样本，记录了有关近期饮酒水平、发病情况、药物治疗和吸烟的标准化数据。根据饮酒量和 CAGE 测试确定 CDT、GGT 和 MCV 的运行特征。计算敏感性、特异性和受试者工作特征曲线，以比较不同截止值下的测试。
结果
21% 的男性和 7% 的女性 CDT 水平升高。根据男性近期饮酒量（> 60 g/d），检测的敏感性和特异性分别为：CDT 为 0.58 和 0.82，GGT 为 0.69 和 0.65，MCV 为 0.27 和 0.91。总体而言，受试者工作特征曲线表明，筛查过量饮酒或酗酒的三种测试的性能相似。然而，在年轻男性（< 40 岁）和吸烟者中，CDT 优于 GGT 或 MCV。
结论
该研究表明，CDT 测定可能是筛查年轻男性患者过量饮酒项目的有用测试。
BACKGROUND
Screening medical patients for excessive alcohol drinking is important because minimal intervention by physicians is effective in reducing excessive consumption. Screening tests, such as biologic markers of alcohol consumption, should therefore be investigated to assess their validity to detect alcohol drinking.
METHOD
Levels of carbohydrate-deficient transferrin (CDT), gamma-glutamyltransferase (GGT), and mean corpuscular volume (MCV) were determined in 1202 consecutive patients (20 to 75 years old) seen at the medical emergency ward (n = 552) and the primary care center (n = 650) of a city and teaching hospital. Each eligible patient was administered a CAGE questionnaire (an acronym for questions regarding cutting down on drinking, annoyance at others' concern about drinking, feeling guilty about drinking, and using alcohol as an eye-opener in the morning), and for each CAGE-positive patient (score > or = 2) as well as for a random sex-matched sample of CAGE-negative patients, standardized data about the recent level of alcohol drinking, morbidities, drug therapy, and smoking were recorded. The operating characteristics of CDT, GGT, and MCV were determined according to alcohol consumption and the CAGE test. Sensitivities, specificities, and receiver operating characteristic curves were computed to compare the tests at different cutoff values.
RESULTS
Levels of CDT were elevated in 21% of men and 7% of women. According to recent alcohol consumption in men (> 60 g/d), the respective sensitivity and specificity of the tests were 0.58 and 0.82 for CDT, 0.69 and 0.65 for GGT, and 0.27 and 0.91 for MCV. Overall, receiver operating characteristic curves demonstrated similar performance of the three tests for screening of excessive alcohol drinking or alcohol abuse. However, in young men (< 40 years of age) and in smokers, CDT was superior to GGT or MCV.
CONCLUSIONS
The study suggests that CDT determination may be a useful test for screening programs of excessive alcohol drinking in young male medical patients.
通过等电聚焦/蛋白质印迹和微阴离子交换色谱/放射免疫分析测量碳水化合物缺乏的转铁蛋白：诊断准确性的比较。
DOI：
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发表时间：
1992
期刊：
Alcohol and alcoholism (Oxford, Oxfordshire)
影响因子：
--
作者：
Xin,Y;Rosman,AS;Lasker,JM;Lieber,CS
通讯作者：
Lieber,CS
戒酒后缺乏碳水化合物的转铁蛋白水平发生变化。
DOI：
10.1111/j.1530-0277.1988.tb00239.x
发表时间：
1988
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Behrens,UJ;Worner,TM;Lieber,CS
通讯作者：
Lieber,CS