Genetic and cellular mechanisms regulating anterior foregut and esophageal development.
Genetic and cellular mechanisms regulating anterior foregut and esophageal development.
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DOI：
10.1016/j.ydbio.2012.06.016
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发表时间：
2012-09-01
影响因子：
2.7
通讯作者：
Que, Jianwen
中科院分区：
文献类型：
--
作者：
Jacobs, Ian J.;Ku, Wei-Yao;Que, Jianwen
单个前肠管分离进入食管和气管，涉及细胞增殖和分化，以及细胞-细胞粘附和迁移的动态变化。这些生物过程通过上皮和间质的相互作用在多个水平上进行调节和协调。遗传研究和体外模型揭示了包括许多转录因子和信号通路在内的相关调控网络。在分离过程发生之前，这些信号分子表现出独特的表达模式，并在各自的领域发挥特定的功能。调节网络的破坏不可避免地导致气管和食道分离缺陷和畸形，并导致形成一种相对常见的出生缺陷，即食管闭锁伴或不伴气管食管瘘（EA/TEF）。值得注意的是，一些参与前肠分离的信号通路和转录因子在个体器官的形态发生中继续发挥重要作用。在这篇综述中，我们将重点关注与这些不同发育过程相关的新发现，并在临床常见的发育障碍（或出生缺陷）的背景下讨论它们。
Separation of the single anterior foregut tube into the esophagus and trachea involves cell proliferation and differentiation, as well as dynamic changes in cell-cell adhesion and migration. These biological processes are regulated and coordinated at multiple levels through the interplay of the epithelium and mesenchyme. Genetic studies and in vitro modeling have shed light on relevant regulatory networks that include a number of transcription factors and signaling pathways. These signaling molecules exhibit unique expression patterns and play specific functions in their respective territories before the separation process occurs. Disruption of regulatory networks inevitably leads to defective separation and malformation of the trachea and esophagus and results in the formation of a relatively common birth defect, esophageal atresia with or without tracheoesophageal fistula (EA/TEF). Significantly, some of the signaling pathways and transcription factors involved in anterior foregut separation continue to play important roles in the morphogenesis of the individual organs. In this review, we will focus on new findings related to these different developmental processes and discuss them in the context of developmental disorders (or birth defects) commonly seen in clinics.
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