Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice.
Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice.
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DOI：
10.1016/j.stem.2011.09.001
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发表时间：
2011-10-04
期刊：
影响因子：
23.9
通讯作者：
Hochedlinger, Konrad
中科院分区：
文献类型：
--
作者：
Arnold, Katrin;Sarkar, Abby;Yram, Mary Anna;Polo, Jose M.;Bronson, Rod;Sengupta, Sumitra;Seandel, Marco;Geijsen, Niels;Hochedlinger, Konrad
转录因子Sox 2维持早期胚胎细胞的多能性，并在胎儿发育期间调节几种上皮细胞的形成。Sox 2是否继续在成人组织中发挥作用仍然是未知的。我们在这里表明，Sox 2标志着成人细胞在几个上皮组织中，它的表达还没有以前的特点，包括胃，子宫颈，肛门，睾丸，透镜和多个腺体。遗传谱系追踪和移植实验表明，表达Sox 2的细胞在这些组织中不断产生成熟细胞类型，记录了它们的自我更新和分化潜力。与这些发现一致，小鼠中Sox 2+细胞的消融导致上皮组织稳态的破坏和致死性。发育命运定位显示Sox2+成体干细胞来源于胎儿Sox2+组织祖细胞。因此，我们的研究结果确定了Sox2在许多成人外胚层和内胚层干细胞隔室中的表达，这对正常组织再生和存活至关重要。
The transcription factor Sox2 maintains the pluripotency of early embryonic cells and regulates the formation of several epithelia during fetal development. Whether Sox2 continues to play a role in adult tissues remains largely unknown. We here show that Sox2 marks adult cells in several epithelial tissues where its expression has not previously been characterized, including the stomach, cervix, anus, testes, lens and multiple glands. Genetic lineage tracing and transplantation experiments demonstrate that Sox2-expressing cells continuously give rise to mature cell types within these tissues, documenting their self-renewal and differentiation potentials. Consistent with these findings, ablation of Sox2+ cells in mice results in a disruption of epithelial tissue homeostasis and lethality. Developmental fate mapping reveals that Sox2+ adult stem cells originate from fetal Sox2+ tissue progenitors. Thus, our results identify Sox2 expression in numerous adult ectodermal and endodermal stem cell compartments, which are critical for normal tissue regeneration and survival.
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DOI：
10.1083/jcb.200409182
发表时间：
2005-03-28
期刊：
The Journal of cell biology
影响因子：
--
作者：
Mansukhani A;Ambrosetti D;Holmes G;Cornivelli L;Basilico C
通讯作者：
Basilico C
影响因子：
23.9
作者：
Ko, Kinarm;Tapia, Natalia;Schoeler, Hans R.
通讯作者：
Schoeler, Hans R.
DOI：
10.1006/bbrc.1997.7124
发表时间：
1997-08-28
影响因子：
3.1
作者：
Feil, R;Wagner, J;Chambon, P
通讯作者：
Chambon, P
影响因子：
30.8
作者：
Bass, Adam J.;Watanabe, Hideo;Mermel, Craig H.;Yu, Soyoung;Perner, Sven;Verhaak, Roel G.;Kim, So Young;Wardwell, Leslie;Tamayo, Pablo;Gat-Viks, Irit;Ramos, Alex H.;Woo, Michele S.;Weir, Barbara A.;Getz, Gad;Beroukhim, Rameen;O'Kelly, Michael;Dutt, Amit;Rozenblatt-Rosen, Orit;Dziunycz, Piotr;Komisarof, Justin;Chirieac, Lucian R.;LaFargue, Christopher J.;Scheble, Veit;Wilbertz, Theresia;Ma, Changqing;Rao, Shilpa;Nakagawa, Hiroshi;Stairs, Douglas B.;Lin, Lin;Giordano, Thomas J.;Wagner, Patrick;Minna, John D.;Gazdar, Adi F.;Zhu, Chang Qi;Brose, Marcia S.;Cecconello, Ivan;Ribeiro, Ulysses, Jr.;Marie, Suely K.;Dahl, Olav;Shivdasani, Ramesh A.;Tsao, Ming-Sound;Rubin, Mark A.;Wong, Kwok K.;Regev, Aviv;Hahn, William C.;Beer, David G.;Rustgi, Anil K.;Meyerson, Matthew
通讯作者：
Meyerson, Matthew
影响因子：
64.8
作者：
Kiernan, AE;Pelling, AL;Cheah, KSE
通讯作者：
Cheah, KSE