Investigating the spatial interaction of immune cells in colon cancer.
Investigating the spatial interaction of immune cells in colon cancer.
复制标题
研究结肠癌中免疫细胞的空间相互作用。
DOI：
10.1016/j.isci.2023.106596
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发表时间：
2023-05-19
期刊：
影响因子：
5.8
通讯作者：
Shahriyari, Leili
中科院分区：
文献类型：
--
作者：
Mirzaei, Navid Mohammad;Hao, Wenrui;Shahriyari, Leili
肿瘤微环境中细胞和分子之间错综复杂的相互作用网络创造了一个异质的生态系统。细胞和分子与其激活剂和抑制剂的接近在肿瘤的进展中是必不可少的。在这里，我们开发了一个系统的偏微分方程耦合线性弹性，以调查空间相互作用对肿瘤微环境的影响。我们观察到有趣的细胞和细胞因子分布模式，这是严重影响巨噬细胞。我们还看到细胞毒性T细胞在巨噬细胞部位被招募和抑制。此外，我们观察到抗肿瘤巨噬细胞重组模式，有利于空间上更受限制的癌症和坏死核心。此外，基于伴随的敏感性分析表明，最敏感的模型的参数是直接相关的巨噬细胞。这些结果强调了巨噬细胞在控制癌细胞群体和在肿瘤微环境中空间排列细胞方面的广泛认可的作用。免疫细胞共定位控制肿瘤微环境中的动力学和模式巨噬细胞严重影响结直肠肿瘤微环境中的模式我们使用生物力学模型来识别负责空间排列的细胞巨噬细胞极化在排列结直肠肿瘤微环境中至关重要生物物理学;癌症系统生物学;免疫学;数学生物科学
The intricate network of interactions between cells and molecules in the tumor microenvironment creates a heterogeneous ecosystem. The proximity of the cells and molecules to their activators and inhibitors is essential in the progression of tumors. Here, we develop a system of partial differential equations coupled with linear elasticity to investigate the effects of spatial interactions on the tumor microenvironment. We observe interesting cell and cytokine distribution patterns, which are heavily affected by macrophages. We also see that cytotoxic T cells get recruited and suppressed at the site of macrophages. Moreover, we observe that anti-tumor macrophages reorganize the patterns in favor of a more spatially restricted cancer and necrotic core. Furthermore, the adjoint-based sensitivity analysis indicates that the most sensitive model’s parameters are directly related to macrophages. The results emphasize the widely acknowledged effect of macrophages in controlling cancer cells population and spatially arranging cells in the tumor microenvironment. Immune cell colocalizations control dynamics and patterns in the tumor microenvironment Macrophages heavily affect the patterns in the colorectal tumor microenvironment We use a biomechanical model to identify cells responsible for spatial arrangements Macrophage polarization is crucial in arranging the colorectal tumor microenvironment Biophysics; Cancer systems biology; Immunology; Mathematical biosciences
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影响因子：
4.9
作者：
Carniel, Emanuele Luigi;Gramigna, Vera;Natali, Arturo N.
通讯作者：
Natali, Arturo N.
DOI：
10.1073/pnas.1815345116
发表时间：
2019-01-02
影响因子：
11.1
作者：
Bocci, Federico;Gearhart-Serna, Larisa;Jolly, Mohit Kumar
通讯作者：
Jolly, Mohit Kumar
影响因子：
1.9
作者：
Franks, SJ;Byrne, HM;Lewis, CE
通讯作者：
Lewis, CE
影响因子：
50.3
作者：
Engelhardt JJ;Boldajipour B;Beemiller P;Pandurangi P;Sorensen C;Werb Z;Egeblad M;Krummel MF
通讯作者：
Krummel MF
影响因子：
0.2
作者：
Devi, Mani;Vijayalakshmi, Dhanaraj;Janane, Murali
通讯作者：
Janane, Murali