Infiltration of M2 Macrophages and Regulatory T Cells Plays a Role in Recurrence of Renal Cell Carcinoma.
Infiltration of M2 Macrophages and Regulatory T Cells Plays a Role in Recurrence of Renal Cell Carcinoma.
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M2巨噬细胞和调节性T细胞的浸润在肾细胞癌复发中发挥作用
DOI：
10.1016/j.euros.2020.06.003
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发表时间：
2020-07
影响因子：
2.5
通讯作者：
Carlsson J
中科院分区：
文献类型：
--
作者：
Davidsson S;Fiorentino M;Giunchi F;Eriksson M;Erlandsson A;Sundqvist P;Carlsson J
据推测，M2巨噬细胞和调节性T细胞（T细胞）可能通过抑制抗肿瘤免疫促进肿瘤进展。探讨CD 163 + M2巨噬细胞和CD 4 + FOXP 3 + T细胞浸润与肾癌患者临床预后的关系。通过免疫组织化学评价了1986年至2011年在Örebro大学医院诊断为肾细胞癌的346例患者的CD 163 + M2巨噬细胞和CD 4 + FOXP 3 + Treg浸润。临床病理特征与CD 163 + M2巨噬细胞和/或CD 4 + FOXP 3 + T细胞浸润之间的关系用卡方或Fisher精确检验进行估计。对于生存分析，使用Kaplan-Meier曲线和对数秩检验和多变量考克斯比例风险回归模型。我们发现，CD 163 + M2巨噬细胞和CD 4 + FOXP 3 + T细胞浸润与不良临床结局相关。我们的数据进一步表明，CD 163 + M2巨噬细胞和CD 4 + FOXP 3 + T细胞共定位在肿瘤和正常组织中，并且这种共定位可能对肿瘤侵袭性具有协同作用。使用组织微阵列而不是整个切片可能被视为一种限制。CD 163 + M2巨噬细胞和CD 4 + FOXP 3 + T细胞浸润与肾细胞癌复发相关，这些细胞类型的共定位可能与临床结局相关。本研究的目的是探讨M2巨噬细胞和调节性T细胞浸润与肾细胞癌临床结局之间的关系。我们证明，这两种细胞类型浸润程度高的肾细胞癌患者临床结局不良的风险增加。调节性T细胞（TCFs）和M2巨噬细胞已被假设为有助于肿瘤进展。我们发现，M2巨噬细胞和TGFAP与更具侵袭性的肾细胞癌相关，并且它们对临床结果具有协同作用。
It has been hypothesized that M2 macrophages and regulatory T cells (Tregs) may contribute to tumor progression by suppression of antitumor immunity. To investigate the association between infiltration of CD163+ M2 macrophages and CD4+FOXP3+ Tregs with clinical outcomes in renal cell carcinoma patients. A cohort of 346 patients diagnosed with renal cell carcinoma at Örebro University Hospital between 1986 and 2011 was evaluated for CD163+ M2 macrophage and CD4+FOXP3+ Treg infiltration by immunohistochemistry. Associations between clinicopathological features and infiltration of CD163+ M2 macrophages and/or CD4+FOXP3+ Tregs were estimated with chi-square or Fisher's exact tests. For survival analyses, Kaplan-Meier curves with log-rank tests and multivariate Cox proportional hazards regression models were used. We found that infiltration of CD163+ M2 macrophages and CD4+FOXP3+ Tregs were associated with adverse clinical outcomes. Our data further demonstrate that CD163+ M2 macrophages and CD4+FOXP3+ Tregs colocalize in tumor and normal tissue, and that this colocalization may have synergistic effects on tumor aggressiveness. The use of tissue microarrays rather than whole sections may be viewed as a limitation. Infiltration of CD163+ M2 macrophages and CD4+FOXP3+ Tregs is associated with recurrence of renal cell carcinoma, and colocalization of these cell types may have an association with clinical outcome. The aim of this study was to investigate the association between infiltration of M2 macrophages and regulatory T cells with clinical outcomes in renal cell carcinoma. We demonstrated that renal cell carcinoma patients with high infiltration of both these cell types are at an increased risk of poor clinical outcomes. Regulatory T cells (Tregs) and M2 macrophages have been hypothesized to contribute to tumor progression. We found that M2 macrophages and Tregs are associated with more aggressive renal cell carcinoma, and that they have a synergistic effect on clinical outcome.
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影响因子：
8.8
作者：
Sun W;Wei FQ;Li WJ;Wei JW;Zhong H;Wen YH;Lei WB;Chen L;Li H;Lin HQ;Iqbal M;Wen WP
通讯作者：
Wen WP
影响因子：
4.6
作者：
Kubota K;Moriyama M;Furukawa S;Rafiul HASM;Maruse Y;Jinno T;Tanaka A;Ohta M;Ishiguro N;Yamauchi M;Sakamoto M;Maehara T;Hayashida JN;Kawano S;Kiyoshima T;Nakamura S
通讯作者：
Nakamura S
影响因子：
2.8
作者：
Erlandsson, Ann;Carlsson, Jessica;Davidsson, Sabina
通讯作者：
Davidsson, Sabina
影响因子：
20.3
作者：
Nishikawa, H;Jäger, E;Gnjatic, S
通讯作者：
Gnjatic, S
影响因子：
4.6
作者：
Shang B;Liu Y;Jiang SJ;Liu Y
通讯作者：
Liu Y