Advances of Exosomal miRNAs in Breast Cancer Progression and Diagnosis.
Advances of Exosomal miRNAs in Breast Cancer Progression and Diagnosis.
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外泌体 miRNA 在乳腺癌进展和诊断中的研究进展
DOI：
10.3390/diagnostics11112151
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发表时间：
2021-11-20
期刊：
影响因子：
--
通讯作者：
Qin J
中科院分区：
文献类型：
--
作者：
Chen W;Li Z;Deng P;Li Z;Xu Y;Li H;Su W;Qin J
乳腺癌是最常见的恶性肿瘤之一，也是全世界妇女癌症死亡的主要原因。虽然许多与乳腺癌相关的因素已被确定，但乳腺癌的确切病因仍不清楚。此外，乳腺癌的早期诊断仍然具有挑战性。Exosomes是由大多数类型的细胞分泌的膜结合的纳米囊泡，含有一系列生物学上重要的分子，如脂质、蛋白质和miRNA等。新的证据表明，exosomes可以通过在细胞之间传递物质和信息来影响细胞的状态，并参与各种生理和病理过程。在乳腺癌中，exosomes通过转移miRNAs在乳腺癌的发生和发展中发挥重要作用，可能成为乳腺癌早期诊断的潜在生物标志物。本文综述了外泌体miRNA在乳腺癌发生、转移、免疫调节、耐药及诊断中的应用。
Breast cancer is one of the most commonly diagnosed malignancies and the leading cause of cancer death in women worldwide. Although many factors associated with breast cancer have been identified, the definite etiology of breast cancer is still unclear. In addition, early diagnosis of breast cancer remains challenging. Exosomes are membrane-bound nanovesicles secreted by most types of cells and contain a series of biologically important molecules, such as lipids, proteins, and miRNAs, etc. Emerging evidence shows that exosomes can affect the status of cells by transmitting substances and messages among cells and are involved in various physiological and pathological processes. In breast cancer, exosomes play a significant role in breast tumorigenesis and progression through transfer miRNAs which can be potential biomarkers for early diagnosis of breast cancer. This review discusses the potential utility of exosomal miRNAs in breast cancer progression such as tumorigenesis, metastasis, immune regulation and drug resistance, and further in breast cancer diagnosis.
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影响因子：
--
作者：
Green TM;Alpaugh ML;Barsky SH;Rappa G;Lorico A
通讯作者：
Lorico A
影响因子：
14.9
作者：
Chen C;Ridzon DA;Broomer AJ;Zhou Z;Lee DH;Nguyen JT;Barbisin M;Xu NL;Mahuvakar VR;Andersen MR;Lao KQ;Livak KJ;Guegler KJ
通讯作者：
Guegler KJ
来自耐药乳腺癌细胞的外泌体通过 MicroRNA 的水平转移传递化疗耐药性
影响因子：
3.7
作者：
Chen WX;Liu XM;Lv MM;Chen L;Zhao JH;Zhong SL;Ji MH;Hu Q;Luo Z;Wu JZ;Tang JH
通讯作者：
Tang JH
影响因子：
14.9
作者：
Baker MB;Bao G;Searles CD
通讯作者：
Searles CD
影响因子：
7.3
作者：
Cummings, Margaret C.;Simpson, Peter T.;Reid, Lynne E.;Jayanthan, Janani;Skerman, Joanna;Song, Sarah;Reed, Amy E. McCart;Kutasovic, Jamie R.;Morey, Adrienne L.;Marquart, Louise;O'Rourke, Peter;Lakhani, Sunil R.
通讯作者：
Lakhani, Sunil R.