Reward modulation of hippocampal subfield activation during successful associative encoding and retrieval.
Reward modulation of hippocampal subfield activation during successful associative encoding and retrieval.
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DOI：
10.1162/jocn_a_00237
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发表时间：
2012-07
影响因子：
3.2
通讯作者：
Preston AR
中科院分区：
文献类型：
--
作者：
Wolosin SM;Zeithamova D;Preston AR
新出现的证据表明，动机通过内侧颞叶（MTL）结构和多巴胺能中脑之间的相互作用增强情景记忆的形成。此外，最近的理论提出，动机特别促进海马体的关联绑定过程，导致更详细的记忆，很容易从部分输入恢复。在这里，我们使用高分辨率的功能磁共振成像，以确定动机如何影响人类MTL亚区和多巴胺能中脑内的关联编码和检索过程。参与者有意编码对象协会在不同条件下的奖励和执行检索任务，在此期间，研究协会的线索从部分输入。行为上，线索回忆性能上级高价值相对于低价值的协会，然而，参与者在奖励影响记忆的程度不同。行为奖励调制的幅度与奖励相关的激活变化在齿状回/CA 2，3在编码和增强的功能之间的连接齿状回/CA 2，3和多巴胺能中脑在编码和检索阶段的任务。这些发现表明，在海马，奖励为基础的动机，特别是增强齿状回/CA 2，3通过与多巴胺能中脑的相互作用的关联编码机制。此外，在海马旁皮质和多巴胺能中脑区域，与成功的记忆形成相关的激活被整个组的奖励调制。在提取阶段，我们还观察到海马和多巴胺能中脑的激活增强，在没有任何明确的奖励线索的情况下发生高价值的协会。总的来说，这些发现揭示了奖励通过促进MTL和VTA/SN加工影响联想记忆形成和提取的基本机制。
Emerging evidence suggests that motivation enhances episodic memory formation through interactions between medial temporal lobe (MTL) structures and dopaminergic midbrain. In addition, recent theories propose that motivation specifically facilitates hippocampal associative binding processes, resulting in more detailed memories that are readily reinstated from partial input. Here, we used high-resolution functional magnetic resonance imaging to determine how motivation influences associative encoding and retrieval processes within human MTL subregions and dopaminergic midbrain. Participants intentionally encoded object associations under varying conditions of reward and performed a retrieval task during which studied associations were cued from partial input. Behaviorally, cued recall performance was superior for high-value relative to low-value associations; however, participants differed in the degree to which rewards influenced memory. The magnitude of behavioral reward modulation was associated with reward-related activation changes in dentate gyrus/CA2,3 during encoding and enhanced functional connectivity between dentate gyrus/CA2,3 and dopaminergic midbrain during both the encoding and retrieval phases of the task. These findings suggests that within the hippocampus, reward-based motivation specifically enhances dentate gyrus/CA2,3 associative encoding mechanisms through interactions with dopaminergic midbrain. Furthermore, within parahippocampal cortex and dopaminergic midbrain regions, activation associated with successful memory formation was modulated by reward across the group. During the retrieval phase, we also observed enhanced activation in hippocampus and dopaminergic midbrain for high-value associations that occurred in the absence of any explicit cues to reward. Collectively, these findings shed light on fundamental mechanisms through which reward impacts associative memory formation and retrieval through facilitation of MTL and VTA/SN processing.
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影响因子：
3.7
作者：
Granado, Noelia;Ortiz, Oskar;Moratalla, Rosario
通讯作者：
Moratalla, Rosario
使用高分辨率功能磁共振成像对人类内侧颞叶进行成像。
影响因子：
16.2
作者：
Carr, Valerie A.;Rissman, Jesse;Wagner, Anthony D.
通讯作者：
Wagner, Anthony D.
影响因子：
16.2
作者：
Bunzeck, Nico;Duzel, Emrah
通讯作者：
Duzel, Emrah
影响因子：
16.2
作者：
Bar, M;Aminoff, E
通讯作者：
Aminoff, E
影响因子：
3.4
作者：
Blaha, CD;Yang, CR;Phillips, AG
通讯作者：
Phillips, AG