Naringin Relieves Diabetic Cardiac Autonomic Neuropathy Mediated by P2Y(14) Receptor in Superior Cervical Ganglion.
Naringin Relieves Diabetic Cardiac Autonomic Neuropathy Mediated by P2Y(14) Receptor in Superior Cervical Ganglion.
复制标题
柚皮苷可缓解颈上神经节 P2Y14 受体介导的糖尿病心脏自主神经病变
DOI：
10.3389/fphar.2022.873090
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发表时间：
2022
影响因子：
5.6
通讯作者：
Li, Guilin
中科院分区：
文献类型：
--
作者：
Tang, Gan;Pi, Lingzhi;Guo, Hongmin;Hu, Zihui;Zhou, Congfa;Hu, Qixing;Peng, Hao;Xiao, Zehao;Zhang, Zhihua;Wang, Miaomiao;Peng, Taotao;Huang, Jiaqi;Liang, Shangdong;Li, Guilin
关键词：
Diabetes mellitus (DM), an emerging chronic epidemic, contributes to mortality and morbidity around the world. Diabetic cardiac autonomic neuropathy (DCAN) is one of the most common complications associated with DM. Previous studies have shown that satellite glial cells (SGCs) in the superior cervical ganglia (SCG) play an indispensable role in DCAN progression. In addition, it has been shown that purinergic neurotransmitters, as well as metabotropic GPCRs, are involved in the pathophysiological process of DCAN. Furthermore, one traditional Chinese medicine, naringin may potently alleviate the effects of DCAN. Ferroptosis may be involved in DCAN progression. However, the role of naringin in DCAN as well as its detailed mechanism requires further investigation. In this research, we attempted to identify the effect and relevant mechanism of naringin in DCAN mitigation. We observed that compared with those of normal subjects, there were significantly elevated expression levels of P2Y14 and IL-1β in diabetic rats, both of which were remarkably diminished by treatment with either P2Y14 shRNA or naringin. In addition, abnormalities in blood pressure (BP), heart rate (HR), heart rate variability (HRV), sympathetic nerve discharge (SND), and cardiac structure in the diabetic model can also be partially returned to normal through the use of those treatments. Furthermore, a reduced expression of NRF2 and GPX4, as well as an elevated level of ROS, were detected in diabetic cases, which can also be improved with those treatments. Our results showed that naringin can effectively relieve DCAN mediated by the P2Y14 receptor of SGCs in the SCG. Moreover, the NRF2/GPX4 pathway involved in ferroptosis may become one of the principal mechanisms participating in DCAN progression, which can be modulated by P2Y14-targeted naringin and thus relieve DCAN. Hopefully, our research can supply one novel therapeutic target and provide a brilliant perspective for the treatment of DCAN.
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影响因子：
16.2
作者：
American Diabetes Association
通讯作者：
American Diabetes Association
影响因子：
--
作者：
Agashe, Shruti;Petak, Steven
通讯作者：
Petak, Steven
影响因子：
3.8
作者：
Chen, Rui;Qi, Qiao-Ling;Li, Qi-Yan
通讯作者：
Li, Qi-Yan
影响因子：
3.6
作者：
Carter, Rhonda L.;Fricks, Ingrid P.;Harden, T. Kendall
通讯作者：
Harden, T. Kendall
影响因子：
15.9
作者：
Cho, Joonseok;Yusuf, Rushdia;Lee, Byeong Chel
通讯作者：
Lee, Byeong Chel