Involvement of Reduced Microbial Diversity in Inflammatory Bowel Disease.
Involvement of Reduced Microbial Diversity in Inflammatory Bowel Disease.
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DOI：
10.1155/2016/6951091
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发表时间：
2016
影响因子：
2
通讯作者：
Dong Q
中科院分区：
文献类型：
--
作者：
Gong D;Gong X;Wang L;Yu X;Dong Q
已经进行了相当多的研究来研究炎症条件下的微生物谱。炎症性肠病（IBD）的一个常见现象是微生物群多样性的减少，这表明微生物多样性与IBD疾病严重程度呈负相关。已知微生物多样性增加发生在疾病缓解期。物种多样性对维持肠道生态系统的稳定和正常的生态功能具有重要作用。微生物多样性的减少与生态系统稳定性的下降相对应，并可能损害生态功能。粪便微生物群移植（FMT），益生菌和益生元，旨在调节微生物群和恢复其正常多样性，已被证明是临床有效的。在这项研究中，我们假设微生物多样性的减少可能在IBD的发展中发挥作用。
A considerable number of studies have been conducted to study the microbial profiles in inflammatory conditions. A common phenomenon in inflammatory bowel disease (IBD) is the reduction of the diversity of microbiota, which demonstrates that microbial diversity negatively correlates with disease severity in IBD. Increased microbial diversity is known to occur in disease remission. Species diversity plays an important role in maintaining the stability of the intestinal ecosystem as well as normal ecological function. A reduction in microbial diversity corresponds to a decrease in the stability of the ecosystem and can impair ecological function. Fecal microbiota transplantation (FMT), probiotics, and prebiotics, which aim to modulate the microbiota and restore its normal diversity, have been shown to be clinically efficacious. In this study, we hypothesized that a reduction in microbial diversity could play a role in the development of IBD.
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DOI：
10.1016/j.ijantimicag.2014.04.020
发表时间：
2014-08-01
影响因子：
10.8
作者：
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通讯作者：
Raoult, Didier
影响因子：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Li, Ellen
影响因子：
8
作者：
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通讯作者：
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