Quantitative Three-Dimensional Dynamic Contrast-Enhanced Ultrasound Imaging: First-In-Human Pilot Study in Patients with Liver Metastases.
Quantitative Three-Dimensional Dynamic Contrast-Enhanced Ultrasound Imaging: First-In-Human Pilot Study in Patients with Liver Metastases.
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DOI：
10.7150/thno.20329
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发表时间：
2017
期刊：
影响因子：
12.4
通讯作者：
Willmann JK
中科院分区：
文献类型：
--
作者：
El Kaffas A;Sigrist RMS;Fisher G;Bachawal S;Liau J;Wang H;Karanany A;Durot I;Rosenberg J;Hristov D;Willmann JK
目的：对肝转移患者进行定量三维（3D）动态超声造影（DCE-US）的可行性和可重复性进行临床评估，并评估与 3D DCE-US 成像相比 2D 定量灌注参数采样误差的程度。材料和方法：对 11 名患者（45% 女性；平均年龄，54.5 岁；范围，48-60 岁；55% 男性；平均年龄，57.6 岁；范围，47-68 岁）进行了 20 次连续 3D DCE-US 扫描。采集成对的重复破坏-补充和推注 DCE-US 图像以确定参数的可重复性。通过在 8 分钟内注入稀释在 35.1 mL 盐水中的 0.9 mL 微泡（Definity；Latheus Medical Imaging）来进行破坏-补充。推注包括静脉注射 0.2 mL 微泡。两个不同的读取器对图像中的感兴趣体积 (VOI) 和感兴趣区域 (ROI) 进行分割，分别提取 3D 和 2D 灌注参数。中断-补充参数为：相对血容量（rBV）、相对血流量（rBF）。推注参数包括：峰值时间 (TP)、峰值增强 (PE)、曲线下面积 (AUC) 和平均通过时间 (MTT)。结果：证明了使用破坏-补充和推注技术的 3D DCE-US 的临床可行性和可重复性。使用一致性相关系数 (CCC) 评估重复采集对之间 3D 测量的可重复性，发现除 TP (0.74) 和 MTT (0.30) 参数外，所有参数 (CCC > 0.80) 都非常出色。除 TP (0.71) 和 MTT (0.52) 外，所有参数的读者之间的 CCC 都非常出色 (CCC > 0.80)。二维参数的肿瘤内测量存在较大的变异系数 (COV) (0.18-0.52)。相同肿瘤的 3D 测量结果与 2D 测量结果显着不同 (P = 0.001)；在同一肿瘤中，2D 测量与 3D 测量之间的百分比差异高达 86%。结论：使用矩阵阵列换能器对肝转移进行 3D DCE-US 成像在临床上是可行且可重复的。结果支持 3D 而不是 2D DCE US 成像，以最大限度地减少由于肿瘤异质性而导致的采样误差。
Purpose: To perform a clinical assessment of quantitative three-dimensional (3D) dynamic contrast-enhanced ultrasound (DCE-US) feasibility and repeatability in patients with liver metastasis, and to evaluate the extent of quantitative perfusion parameter sampling errors in 2D compared to 3D DCE-US imaging. Materials and Methods: Twenty consecutive 3D DCE-US scans of liver metastases were performed in 11 patients (45% women; mean age, 54.5 years; range, 48-60 years; 55% men; mean age, 57.6 years; range, 47-68 years). Pairs of repeated disruption-replenishment and bolus DCE-US images were acquired to determine repeatability of parameters. Disruption-replenishment was carried out by infusing 0.9 mL of microbubbles (Definity; Latheus Medical Imaging) diluted in 35.1 mL of saline over 8 min. Bolus consisted of intravenous injection of 0.2 mL microbubbles. Volumes-of-interest (VOI) and regions-or-interest (ROI) were segmented by two different readers in images to extract 3D and 2D perfusion parameters, respectively. Disruption-replenishment parameters were: relative blood volume (rBV), relative blood flow (rBF). Bolus parameters included: time-to-peak (TP), peak enhancement (PE), area-under-the-curve (AUC), and mean-transit-time (MTT). Results: Clinical feasibility and repeatability of 3D DCE-US using both the destruction-replenishment and bolus technique was demonstrated. The repeatability of 3D measurements between pairs of repeated acquisitions was assessed with the concordance correlation coefficient (CCC), and found to be excellent for all parameters (CCC > 0.80), except for the TP (0.74) and MTT (0.30) parameters. The CCC between readers was found to be excellent (CCC > 0.80) for all parameters except for TP (0.71) and MTT (0.52). There was a large Coefficient of Variation (COV) in intra-tumor measurements for 2D parameters (0.18-0.52). Same-tumor measurements made in 3D were significantly different (P = 0.001) than measurements made in 2D; a percent difference of up to 86% was observed between measurements made in 2D compared to 3D in the same tumor. Conclusions: 3D DCE-US imaging of liver metastases with a matrix array transducer is feasible and repeatable in the clinic. Results support 3D instead of 2D DCE US imaging to minimize sampling errors due to tumor heterogeneity.
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DOI：
10.7863/jum.2010.29.4.577
发表时间：
2010-04
期刊：
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
影响因子：
--
作者：
Hoyt K;Warram JM;Umphrey H;Belt L;Lockhart ME;Robbin ML;Zinn KR
通讯作者：
Zinn KR
影响因子：
5.7
作者：
Nagy JA;Chang SH;Shih SC;Dvorak AM;Dvorak HF
通讯作者：
Dvorak HF
影响因子：
2.4
作者：
Arlt, Felix;Chalopin, Claire;Lindner, Dirk
通讯作者：
Lindner, Dirk
影响因子：
2.3
作者：
Eisenbrey, John R.;Daecher, Annemarie;Forsberg, Flemming
通讯作者：
Forsberg, Flemming
影响因子：
11.5
作者：
Lassau, Nathalie;Koscielny, Serge;Escudier, Bernard J.
通讯作者：
Escudier, Bernard J.