Growth factor signaling: implications for disease & therapeutics.
Growth factor signaling: implications for disease & therapeutics.
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DOI：
10.1007/s11481-014-9534-4
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发表时间：
2014-03
影响因子：
6.2
通讯作者：
Buch, Shilpa
中科院分区：
文献类型：
--
作者：
Buch, Shilpa
关键词：
细胞拥有复杂的生长因子网络，在调节基本生命过程中发挥重要作用。此类蛋白质因子通过与相关细胞特异性受体结合来发挥作用，从而调节细胞分裂、分化、趋化性或细胞凋亡。受体通过其各自的配体的接合导致连续的蛋白质磷酸化级联的激活，在下游达到顶峰以激活基因转录。这些因子在各种条件下由正常细胞以及转化细胞普遍表达，从而在几种生理和病理条件下支持它们在细胞的自分泌和旁分泌刺激中的功能。尽管我们对生长因子的理解取得了重大进展，但它们在正常细胞内稳态和病理中的矛盾作用支持了研究它们在疾病和健康中作用的必要性。这期特刊的目标是呈现生长因子在炎症性疾病过程中所起作用的新趋势，这些疾病包括心血管、癌症、中风和与衰老、病毒感染和药物滥用相关的神经退行性过程，最终目的是为未来的治疗突破铺平道路。
Cells possess complex growth factor networks that play vital roles in regulating fundamental life processes. Such protein factors exert their action by binding to cognate cell specific receptors resulting in regulation of cell division, differentiation, chemotaxis or apoptosis. Engagement of receptors by their respective ligands results in activation of sequential protein phosphorylation cascade, culminating downstream into activation of gene transcription. These factors are expressed ubiquitously under a variety of conditions by normal as well as transformed cells, thereby underpinning their function in autocrine and paracrine stimulation of cells under several physiological and pathological conditions. Despite major advances in our understanding of growth factors, their paradoxical roles in normal cellular homeostasis and pathologies underpin the need to examine their roles in disease and health. The goal of this special issue is to present emerging trends in the roles that growth factors play in inflammatory disease processes that include cardiovascular, cancer, stroke and neurodegenerative processes associated with aging, viral infection and substance abuse with the ultimate aim to pave the way for future therapeutic breakthroughs.
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DOI：
10.1073/pnas.182296499
发表时间：
2002-09-03
影响因子：
11.1
作者：
Jin, KL;Zhu, YH;Greenberg, DA
通讯作者：
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DOI：
10.1523/jneurosci.0865-12.2012
发表时间：
2012-07-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
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作者：
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影响因子：
6.2
作者：
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通讯作者：
Roy, Sabita
影响因子：
14.5
作者：
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DOI：
10.1073/pnas.95.24.14500
发表时间：
1998-11-24
影响因子：
11.1
作者：
Meucci, O;Fatatis, A;Miller, RJ
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Miller, RJ