Amino acid metabolism and autophagy in skeletal development and homeostasis.
Amino acid metabolism and autophagy in skeletal development and homeostasis.
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DOI：
10.1016/j.bone.2021.115881
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发表时间：
2021-05
期刊：
影响因子：
4.1
通讯作者：
Iwata J
中科院分区：
文献类型：
--
作者：
Suzuki A;Iwata J
骨是一个活跃的器官，在整个生命过程中通过形成和吸收不断重塑;因此，微调骨（重新）建模对于骨稳态至关重要，并与能量代谢密切相关。氨基酸是各种细胞功能所必需的，也是能量来源，其合成和代谢（例如，碳水化合物和脂肪酸的代谢）通过许多酶级联调节。此外，细胞内的氨基酸水平通过自噬来维持，自噬是蛋白质和细胞器的细胞再循环系统;在营养缺乏条件下，自噬被强烈诱导以补偿细胞需求并恢复氨基酸库。已知衍生自氨基酸的代谢产物是生物活性分子如第二信使和神经递质的前体，其控制各种细胞过程，包括细胞增殖、分化和稳态。因此，氨基酸代谢和自噬在我们的身体中受到严格和严格的调节。本文综述了目前的知识和骨疾病和氨基酸代谢和自噬缺陷之间的潜在联系。
Bone is an active organ that is continuously remodeled throughout life via formation and resorption; therefore, a fine-tuned bone (re)modeling is crucial for bone homeostasis and is closely connected with energy metabolism. Amino acids are essential for various cellular functions as well as an energy source, and their synthesis and catabolism (e.g., metabolism of carbohydrates and fatty acids) are regulated through numerous enzymatic cascades. In addition, the intracellular levels of amino acids are maintained by autophagy, a cellular recycling system for proteins and organelles; under nutrient deprivation conditions, autophagy is strongly induced to compensate for cellular demands and to restore the amino acid pool. Metabolites derived from amino acids are known to be precursors of bioactive molecules such as second messengers and neurotransmitters, which control various cellular processes, including cell proliferation, differentiation, and homeostasis. Thus, amino acid metabolism and autophagy are tightly and reciprocally regulated in our bodies. This review discusses the current knowledge and potential links between bone diseases and deficiencies in amino acid metabolism and autophagy.
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DOI：
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发表时间：
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期刊：
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影响因子：
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影响因子：
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作者：
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期刊：
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影响因子：
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DOI：
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发表时间：
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期刊：
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影响因子：
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