Next-Generation Influenza HA Immunogens and Adjuvants in Pursuit of a Broadly Protective Vaccine.
Next-Generation Influenza HA Immunogens and Adjuvants in Pursuit of a Broadly Protective Vaccine.
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下一代流感 HA 免疫原和佐剂，旨在开发具有广泛保护性的疫苗。
DOI：
10.3390/v13040546
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发表时间：
2021-03-24
期刊：
影响因子：
--
通讯作者：
Mousa JJ
中科院分区：
文献类型：
--
作者：
Nagashima KA;Mousa JJ
流感病毒是一种高度可变的呼吸道病原体，几乎每年都会引起重大疾病。目前的疫苗是为了防止特定季节的流行性流感病毒株。然而，疫苗株和流行株之间的错配，以及免疫缺陷人群中较差的疫苗有效性，是主要的障碍。为了扩大流感疫苗接种引起的保护范围，主要表面糖蛋白之一血凝素（HA）已被修饰以开发显示来自多种病毒的保守区域或引起高度多克隆抗体应答的免疫原以扩大保护。这些靶向HA的头部或茎部结构域或两个结构域的方法在最近的临床前和临床研究中显示出前景。此外，已经研究了佐剂在增强体液应答的稳健性中的作用，并且目前正在研究它们对疫苗引发的抗体库的影响。本文将从抗原和佐剂两个方面讨论针对甲型流感病毒的通用流感疫苗领域的进展，重点是广泛中和抗体的诱导。
Influenza virus, a highly mutable respiratory pathogen, causes significant disease nearly every year. Current vaccines are designed to protect against circulating influenza strains of a given season. However, mismatches between vaccine strains and circulating strains, as well as inferior vaccine effectiveness in immunodeficient populations, represent major obstacles. In an effort to expand the breadth of protection elicited by influenza vaccination, one of the major surface glycoproteins, hemagglutinin (HA), has been modified to develop immunogens that display conserved regions from multiple viruses or elicit a highly polyclonal antibody response to broaden protection. These approaches, which target either the head or the stalk domain of HA, or both domains, have shown promise in recent preclinical and clinical studies. Furthermore, the role of adjuvants in bolstering the robustness of the humoral response has been studied, and their effects on the vaccine-elicited antibody repertoire are currently being investigated. This review will discuss the progress made in the universal influenza vaccine field with respect to influenza A viruses from the perspectives of both antigen and adjuvant, with a focus on the elicitation of broadly neutralizing antibodies.
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影响因子：
15.9
作者：
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