The Origin and Pathogenesis of Endometriosis.
The Origin and Pathogenesis of Endometriosis.
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DOI：
10.1146/annurev-pathmechdis-012419-032654
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发表时间：
2020-01-24
期刊：
影响因子：
--
通讯作者：
Shih IM
中科院分区：
文献类型：
--
作者：
Wang Y;Nicholes K;Shih IM
最近关于子宫内膜异位症和正常子宫内膜的分子遗传学研究表明，月经后旨在再生子宫内膜的循环上皮祖细胞或干细胞可能过度反应并被困在子宫外。这些被困的上皮承诺祖细胞通过克隆扩增形成新生腺体并招募多克隆基质细胞，导致深浸润性子宫内膜异位症的建立。一旦形成，异位组织就会受到免疫监视，导致慢性炎症。由核因子-κB信号调控的炎症反应被雌激素受体-β和孕激素受体通路的异常加剧，这些通路也受到局部炎症的影响，形成一个失调的炎症-激素循环。子宫内膜异位症组织内的腺上皮含有与癌症相关的突变，这些突变在子宫内膜异位症相关的卵巢癌中经常被检测到。本文综述了近年来有关子宫内膜异位症发病机制和发病机制的研究进展，为提高子宫内膜异位症的早期诊断和治疗提供了新的研究途径。
Recent molecular genetic findings on endometriosis and normal endometrium suggest a modified model in which circulating epithelial progenitor or stem cells intended to regenerate uterine endometrium after menstruation may become overreactive and trapped outside the uterus. These trapped epithelium-committed progenitor cells form nascent glands through clonal expansion and recruit polyclonal stromal cells, leading to the establishment of deep infiltrating endometriosis. Once formed, the ectopic tissue becomes subject to immune surveillance, resulting in chronic inflammation. The inflammatory response orchestrated by nuclear factor-κB signaling is exacerbated by aberrations in the estrogen receptor-β and progesterone receptor pathways, which are also affected by local inflammation, forming a dysregulated inflammation–hormonal loop. Glandular epithelium within endometriotic tissue harbors cancer-associated mutations that are frequently detected in endometriosis-related ovarian cancers. In this review, we summarize recent advances that have illuminated the origin and pathogenesis of endometriosis and have provided new avenues for research that promise to improve the early diagnosis and management of endometriosis.
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DOI：
10.1056/nejmoa1614814
发表时间：
2017-05-11
期刊：
The New England journal of medicine
影响因子：
--
作者：
Anglesio MS;Papadopoulos N;Ayhan A;Nazeran TM;Noë M;Horlings HM;Lum A;Jones S;Senz J;Seckin T;Ho J;Wu RC;Lac V;Ogawa H;Tessier-Cloutier B;Alhassan R;Wang A;Wang Y;Cohen JD;Wong F;Hasanovic A;Orr N;Zhang M;Popoli M;McMahon W;Wood LD;Mattox A;Allaire C;Segars J;Williams C;Tomasetti C;Boyd N;Kinzler KW;Gilks CB;Diaz L;Wang TL;Vogelstein B;Yong PJ;Huntsman DG;Shih IM
通讯作者：
Shih IM
影响因子：
7.3
作者：
Cheng, Ching-wen;Licence, Diana;Charnock-Jones, D. Stephen
通讯作者：
Charnock-Jones, D. Stephen
影响因子：
7.5
作者：
Ayhan, Ayse;Kuhn, Elisabetta;Wang, Tian-Li
通讯作者：
Wang, Tian-Li
影响因子：
7.3
作者：
Capobianco A;Rovere-Querini P
通讯作者：
Rovere-Querini P
影响因子：
2.7
作者：
Alderman, Myles H., III;Yoder, Nicole;Taylor, Hugh S.
通讯作者：
Taylor, Hugh S.