Genetic architecture of the acute and persistent immune cell response after radiation exposure.
Genetic architecture of the acute and persistent immune cell response after radiation exposure.
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DOI：
10.1016/j.xgen.2023.100422
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发表时间：
2023-11-08
期刊：
影响因子：
--
通讯作者：
Snijders, Antoine M.
中科院分区：
文献类型：
--
作者：
He, Li;Zhong, Chenhan;Chang, Hang;Inman, Jamie L.;Celniker, Susan E.;Ioakeim-Ioannidou, Myrsini;Liu, Kevin X.;Haas-Kogan, Daphne;Macdonald, Shannon M.;Threadgill, David W.;Kogan, Scott C.;Mao, Jian-Hua;Snijders, Antoine M.
血液学毒性是多模式癌症治疗的常见副作用。几乎所有研究放射治疗诱导的血液学毒性原因的动物研究均使用遗传多样性有限的近交系，未反映在人类中观察到的不同反应。我们使用基于群体的协作杂交（CC）小鼠资源，通过测量代表35个品系的1，720只CC小鼠的22个免疫参数，研究辐射暴露后急性和持续免疫应答的遗传结构。考虑到所有免疫参数的贡献，我们确定了个体菌株水平的相对急性和持续辐射抗性评分。全基因组关联分析确定了与基线和辐射反应相关的数量性状位点。一个跨物种的放射抵抗评分预测髓母细胞瘤患者的无复发生存。我们提出了一个社区资源的免疫参数和全基因组的关联分析之前和之后的辐射暴露的宿主遗传学对辐射敏感性的贡献的未来调查。辐射暴露后的血液学毒性在个体之间差异很大GWAS分析鉴定了许多新的辐射敏感性基因在基于群体的小鼠模型中开发了辐射敏感性评分。在基线和辐射暴露后提供免疫参数和全基因组关联分析的社区资源，以调查宿主遗传学对辐射敏感性的贡献。全基因组关联分析发现了许多与辐射敏感性相关的新基因。小鼠到人类的翻译揭示了放射抵抗评分对髓母细胞瘤患者队列无复发生存的预测价值。
Hematologic toxicity is a common side effect of multimodal cancer therapy. Nearly all animal studies investigating the causes of radiotherapy-induced hematologic toxicity use inbred strains with limited genetic diversity and do not reflect the diverse responses observed in humans. We used the population-based Collaborative Cross (CC) mouse resource to investigate the genetic architecture of the acute and persistent immune response after radiation exposure by measuring 22 immune parameters in 1,720 CC mice representing 35 strains. We determined relative acute and persistent radiation resistance scores at the individual strain level considering contributions from all immune parameters. Genome-wide association analysis identified quantitative trait loci associated with baseline and radiation responses. A cross-species radiation resistance score predicted recurrence-free survival in medulloblastoma patients. We present a community resource of immune parameters and genome-wide association analyses before and after radiation exposure for future investigations of the contributions of host genetics on radiosensitivity. Hematologic toxicity after radiation exposure varies widely across individuals GWAS analyses identified many new radiation sensitivity genes A radiation sensitivity score was developed in a population-based mouse model The murine radiation sensitivity score predicts outcome in cancer patients He et al. present a community resource of immune parameters and genome-wide association analyses at baseline and after radiation exposure for investigations of contributions of host genetics on radiosensitivity. Genome-wide association analysis identified many new genes associated with radiation sensitivity. A mouse-to-human translation revealed the predictive value of a radiation resistance score for relapse-free survival in a cohort of medulloblastoma patients.
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影响因子：
14.9
作者：
Groza, Tudor;Gomez, Federico Lopez;Mashhadi, Hamed Haseli;Munoz-Fuentes, Violeta;Gunes, Osman;Wilson, Robert;Cacheiro, Pilar;Frost, Anthony;Keskivali-Bond, Piia;Vardal, Bora;McCoy, Aaron;Cheng, Tsz Kwan;Santos, Luis;Wells, Sara;Smedley, Damian;Mallon, Ann-Marie;Parkinson, Helen
通讯作者：
Parkinson, Helen
影响因子：
3.6
作者：
Baskar R;Lee KA;Yeo R;Yeoh KW
通讯作者：
Yeoh KW
全外显子组测序揭示范可尼贫血患者多个 FA 基因的伴随突变
影响因子：
2.7
作者：
Chang L;Yuan W;Zeng H;Zhou Q;Wei W;Zhou J;Li M;Wang X;Xu M;Yang F;Yang Y;Cheng T;Zhu X
通讯作者：
Zhu X
影响因子：
11.4
作者：
通讯作者：
--
DOI：
10.1016/j.ijrobp.2020.09.049
发表时间：
2021-01-28
影响因子：
7
作者：
Liu, Kevin X.;Ioakeim-Ioannidou, Myrsini;MacDonald, Shannon M.
通讯作者：
MacDonald, Shannon M.