PPARs: diverse regulators in energy metabolism and metabolic diseases.

PPARs: diverse regulators in energy metabolism and metabolic diseases.
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DOI:
10.1038/cr.2010.13
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发表时间:
2010-02
期刊:
影响因子:
44.1
通讯作者:
--
中科院分区:
生物学1区
文献类型:
--
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核受体 PPAR 对于能量稳态至关重要。通过其独特但重叠的功能和组织分布,PPAR 在转录水平上调节能量代谢的许多方面。这些受体的功能损伤或失调会导致多种代谢疾病,而它们的配体则提供许多代谢益处。对这些受体的研究增进了我们对能量代谢转录基础的了解,并帮助我们了解代谢综合征的致病机制。
The nuclear receptor PPARs are fundamentally important for energy homeostasis. Through their distinct yet overlapping functions and tissue distribution, the there PPARs regulate many aspects of energy metabolism at the transcriptional level. Functional impairment or dysregulation of these receptors leads to a variety of metabolic diseases, while their ligands offer many metabolic benefits. Studies of these receptors have advanced our knowledge of the transcriptional basis of energy metabolism and helped us understand the pathogenic mechanisms of metabolic syndrome.
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