Glioma and the gut-brain axis: opportunities and future perspectives.
Glioma and the gut-brain axis: opportunities and future perspectives.
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DOI：
10.1093/noajnl/vdac054
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Esquenazi, Yoshua
中科院分区：
文献类型：
--
作者：
Dono, Antonio;Nickles, Jack;Rodriguez-Armendariz, Ana G.;McFarland, Braden C.;Ajami, Nadim J.;Ballester, Leomar Y.;Wargo, Jennifer A.;Esquenazi, Yoshua
肠脑轴为癌症和中枢神经系统（CNS）疾病的治疗提供了宝贵的新动力。然而，人们对该轴在神经肿瘤学中的潜在作用知之甚少。本综述的目的是强调肠脑轴在神经肿瘤学（特别是神经胶质瘤）和未来研究领域的潜在影响。肠-脑轴是一个完善的生化信号轴，与各种中枢神经系统疾病相关。在神经肿瘤学领域，最近的研究描述了荷瘤小鼠和神经胶质瘤患者与对照组相比肠道微生物组的差异。微生物组组成的这些差异预计会影响每个微生物组的代谢功能。抗生素对微生物组的影响可能会影响荷瘤小鼠的肿瘤生长并调节免疫系统。初步研究表明，肠道微生物组可能会影响胶质瘤小鼠的 PD-L1 反应，正如之前在其他非中枢神经系统癌症中观察到的那样。突破性的研究已经在包括高级别神经胶质瘤在内的多种癌症中发现了瘤内细菌 DNA。肠道微生物组及其操纵代表了一个相对未经探索的新领域，可用于增强神经胶质瘤治疗的有效性。需要对该治疗策略进行进一步的机制研究以评估其临床相关性。
The gut–brain axis has presented a valuable new dynamic in the treatment of cancer and central nervous system (CNS) diseases. However, little is known about the potential role of this axis in neuro-oncology. The goal of this review is to highlight potential implications of the gut–brain axis in neuro-oncology, in particular gliomas, and future areas of research. The gut–brain axis is a well-established biochemical signaling axis that has been associated with various CNS diseases. In neuro-oncology, recent studies have described gut microbiome differences in tumor-bearing mice and glioma patients compared to controls. These differences in the composition of the microbiome are expected to impact the metabolic functionality of each microbiome. The effects of antibiotics on the microbiome may affect tumor growth and modulate the immune system in tumor-bearing mice. Preliminary studies have shown that the gut microbiome might influence PD-L1 response in glioma-bearing mice, as previously observed in other non-CNS cancers. Groundbreaking studies have identified intratumoral bacterial DNA in several cancers including high-grade glioma. The gut microbiome and its manipulation represent a new and relatively unexplored area that could be utilized to enhance the effectiveness of therapy in glioma. Further mechanistic studies of this therapeutic strategy are needed to assess its clinical relevance.
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